Impact of a High-fat Meal on Assessment of Clopidogrel-induced Platelet Inhibition in Healthy Subjects
| Status: | Archived |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | February 2011 |
| End Date: | December 2011 |
The purpose of this study is to determine whether a high-fat meal affects the ability of
platelet function tests to measure platelet inhibition by clopidogrel.
The purpose of this study is to determine the influence of a high-fat meal on assessment of
clopidogrel-induced platelet inhibition in healthy people using platelet function assays.
Twelve healthy adult subjects will be recruited to take part in this research study. After
consent is obtained, subjects will be asked to present to the clinical research center after
a 12 hour fast. A baseline blood sample will be drawn at 8 am, and subjects will then be
administered a 600 mg dose of clopidogrel. At 12 noon, another blood sample will be drawn to
evaluate the extent of maximum platelet inhibition in the fasting state. Subjects will then
be provided a standardized high-fat meal with an additional blood sample at 2 pm to evaluate
the impact of the high-fat on platelet function assessment.
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