Misoprostol Prior to Intrauterine Device (IUD) Insertion in Nulliparous Women
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 14 - 45 |
| Updated: | 7/11/2015 |
| Start Date: | February 2011 |
| End Date: | March 2013 |
| Contact: | Eve Espey, MD/MPH |
| Email: | eespey@salud.unm.edu |
| Phone: | 505-272-3942 |
A Randomized Control Trial of Misoprostol Versus Placebo for Cervical Priming in IUD Insertion for Nulliparous Women
The purpose of this study is to see if using misoprostol makes the intrauterine device
insertion easier and less painful in women who have never had a baby.
insertion easier and less painful in women who have never had a baby.
The Intrauterine Device (IUD) is an excellent contraceptive option because of its ease of
use, long term duration (5-10 years), low side-effect profile, and the immediate return to
fertility after IUD removal. Despite advantages associated with the IUD, the smaller
cervical diameter of nulliparous patients may lead to a more difficult and uncomfortable
insertion. Some providers have started pre-medicating nulliparous patients with misoprostol
prior to IUD insertion because of the drug's known effect as a cervical ripening agent.
Limited evidence is available addressing the effect of misoprostol on patient comfort and
provider ease of IUD insertion in nulliparous women. The goal of this study is to evaluate
whether using misoprostol as a cervical ripening agent in nulliparous patients eases IUD
insertion and decreases pain.
use, long term duration (5-10 years), low side-effect profile, and the immediate return to
fertility after IUD removal. Despite advantages associated with the IUD, the smaller
cervical diameter of nulliparous patients may lead to a more difficult and uncomfortable
insertion. Some providers have started pre-medicating nulliparous patients with misoprostol
prior to IUD insertion because of the drug's known effect as a cervical ripening agent.
Limited evidence is available addressing the effect of misoprostol on patient comfort and
provider ease of IUD insertion in nulliparous women. The goal of this study is to evaluate
whether using misoprostol as a cervical ripening agent in nulliparous patients eases IUD
insertion and decreases pain.
Inclusion Criteria:
- 14 years old or older
- Negative pregnancy test
- No prior pregnancies lasting beyond 19 6/7 weeks
- Minimum 2 weeks after spontaneous or medical abortion
- Minimum 4 weeks post 2nd trimester or surgical abortion
- No previous IUD insertions
- No PID in last 3 months
- No current cervicitis
- Willing to follow-up in 1-2 months for an IUD string check
Exclusion Criteria:
- Active cervical infection
- Current pregnancy
- Prior pregnancy beyond 19 6/7 weeks gestation
- Known uterine anomaly
- Fibroid uterus distorting uterine cavity
- Copper allergy/Wilson's Disease (for Paragard)
- Undiagnosed abnormal uterine bleeding
- Cervical or uterine cancer
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