ESBA1008 Safety, Tolerability and Effects in Wet Age-related Macular Degeneration (AMD) Patients

Inclusion Criteria:

- primary subfoveal choroidal neovascularization (CNV) secondary to AMD, including
predominantly classic, minimally classic or occult lesions in study eye

- a new diagnosis of exudative AMD or evidence of recent disease progression within the
last 3 months in study eye

Exclusion Criteria:

- Study eye must not have been treated for wet AMD previously

- Study eye must not have any other ocular disease, condition, infection or recent
surgery that would interfere with vision or examination of the back of the eye

- Study eye must not have uncontrolled glaucoma and/or must not be missing a lens

- Current use or history of chronic therapy with systemic or topical ocular
corticosteroids

- Must not have medical condition that would preclude scheduled study visits,
completion of study or safe administration of study medication

- Must not have allergies to any component of the test article or sensitivity to
fluorescein dye

- Abnormal screening laboratory result

- Female of childbearing potential who are not using adequate birth control methods.