Cross-Over Study of Subcutaneous Study Drug for the Treatment of Patients With Mild to Moderate Asthma

Inclusion Criteria:

- Subject has provided written informed consent

- The subject is male or female >18 to 65 years of age

- Patient has a clinical history of asthma as defined by the National Asthma Education
and Prevention Program.

- Documented bronchodilator response to albuterol as defined by the American Thoracic
Society (> 200 mL and > 12% increase in FEV1 after bronchodilator inhalation)

- FEV1 post-bronchodilator of between 55% and 80% predicted.

- Currently taking 200-1000 mcg (fluticasone equivalent) of inhaled corticosteroids

- All inclusion criteria met within the past 12 months.

- If the subject or subject's partner is of child-bearing potential, a medically
acceptable form of contraception will be used for three months prior to the screening
visit (females only), for the duration of the study and for one month following the
last dose of the study drug. Medically acceptable contraceptives include: (1)
surgical sterilization, (2) FDA-approved female hormonal contraceptives, (3) an
intrauterine device (IUD), (4) condoms with spermicide, or (5) diaphragm with
spermicide.

If the subject had a vasectomy greater than 6 months prior to the screen visit, this will
also be acceptable.

Exclusion Criteria:

- Current diagnosis, as per subject or investigator or screening assessment, of:

- unstable or uncontrolled disease in any organ system (including cardiovascular)
on present therapy

- psychiatric disease requiring daily medication, including controlled or
uncontrolled schizophrenia or any other uncontrolled psychiatric condition

- significant neurological disease

- current or history of any cancer (except non-melanomatous skin cancer) diagnosed
less than 5 years prior to screening

- acute or chronic disease requiring frequent changes in medications or changes in
dosages of chronic therapy

- history of alcohol abuse within the past 5 years

- positive result for the alcohol and/or drug tests at screening or check-in

- positive for HIV, or Hep B&C at screening

- blood donation within 30 days of screening or plasma donation within 7 days of
screening

- weight > 100 kg or < 50 kg

- clinically significant electrocardiogram (ECG) at screening

- any clinically significant (per the investigator) lab abnormalities

- any fever or other clinically significant physical exam abnormalities

- History of COPD or any other lung disease

- Greater than 10 packs per year smoking history and any cigarette smoking within the
past 12 months

- Patients unable to withhold bronchodilator treatment for 12 hours prior to dosing

- Patients with hypoxia at screen or Check -in Visit 2, Day 1 or Visit 3, Day 7 (oxygen
saturation measured by pulse oximetry [SpO2] < 90%)

- Tachycardia (heart rate > 100 beats/min) at screening

- Currently being treated for Hypertension or taking any other medications that affect
blood pressure significantly.

- Currently taking any medications that inhibit PDE activity or which affect the cyclic
guanisine mono-phosphate (cGMP) pathway (e.g. theophylline). These medications will
be prohibited during the study and for at least 5 half- lives prior to Check-in Visit
2, Day 1 or Visit 3, Day 7 so that cGMP measurements will not be affected.

- Hypotension (systolic blood pressure < 110 mmHg) at Screening or Check-in Visit 2,
Day 1 or Visit 3, Day 7

- Chronic kidney disease defined as estimated glomerular filtration rate (eGFR) <50
mL/m2.

- Diagnosis of heart failure or history of hospitalization for congestive heart
failure.

- History of coronary artery disease defined as prior myocardial infarction, prior
revascularization procedure, or >50% coronary artery obstruction by angiography.

- Prior history of stroke or transient ischemic attack.

- Female patients of childbearing potential who are nursing or have a positive
pregnancy test at Screening or Check -in Visit 2, Day 1 or Visit 3, Day 7

- Any major disability or disease with expected survival less than 6 months

- Administration of any investigational drug or implantation of investigational device,
or participation in another trial, within 30 days of screening.

- Inability to perform acceptable, quality serial spirometry