Allo Transplant Followed by Lenalidomide and Sirolimus Maintenance in High-Risk Multiple Myeloma (MM)
| Status: | Terminated |
|---|---|
| Conditions: | Blood Cancer, Hematology |
| Therapuetic Areas: | Hematology, Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/10/2019 |
| Start Date: | February 7, 2011 |
| End Date: | July 28, 2017 |
Phase I/II Trial of Allogeneic Peripheral Blood Stem Cell Transplantation Followed by Maintenance Therapy With Lenalidomide and Sirolimus in Patients With High-Risk Multiple Myeloma
One of the complications that can occur after a stem cell transplant is called graft versus
host disease (GVHD). Another complication is that multiple myeloma may come back (relapse).
In this study, a drug called lenalidomide will be started 1-2 months after a transplant, or
possibly later depending on recovery of your side effects. Lenalidomide and sirolimus have
been shown to work together against multiple myeloma. Therefore, lenalidomide will be
combined with sirolimus with the hope that this will help prolong the amount of time the
disease is in remission. Researchers hope these steps will help prolong the amount of time
the multiple myeloma is in remission and will decrease the chance of GvHD.
host disease (GVHD). Another complication is that multiple myeloma may come back (relapse).
In this study, a drug called lenalidomide will be started 1-2 months after a transplant, or
possibly later depending on recovery of your side effects. Lenalidomide and sirolimus have
been shown to work together against multiple myeloma. Therefore, lenalidomide will be
combined with sirolimus with the hope that this will help prolong the amount of time the
disease is in remission. Researchers hope these steps will help prolong the amount of time
the multiple myeloma is in remission and will decrease the chance of GvHD.
Recipient Inclusion Criteria:
- 1. Understand and voluntarily sign an informed consent form.
- 2. Age 18-70 years at the time of signing the informed consent form.
- 3. Able to adhere to the study visit schedule and other protocol requirements.
- 4. Previously documented multiple myeloma (MM) with measurable monoclonal protein by
either serum/urine protein electrophoresis or serum free light chains, or measurable
plasmacytomas.
- 5. ECOG performance status of 0-2 at study entry (see Appendix 2).
- 6. Acceptable organ function as outlined in the protocol.
- 7. Otherwise fitting institutional criteria for allogeneic stem cell transplantation.
- 8. Presence of an HLA-matched (5/6 or 6/6 matched for HLA-A, B, and DR) sibling donor,
or a HLA-matched (matched for at least HLA-A, B, C, and DRB1) unrelated donor by
high-resolution testing.
- 9. Disease free of prior malignancies for >/= 5 years with exception of currently
treated basal cell, squamous cell carcinoma of the skin, or carcinoma "insitu" of the
cervix or breast.
- 10. All study participants must be registered into the mandatory RevAssist® program,
and be willing and able to comply with the requirements of RevAssist®.
- 11. Females of childbearing potential (FCBP) must have a negative serum or urine
pregnancy test
Recipient Exclusion Criteria:
- 1. Any serious medical condition, laboratory abnormality, or psychiatric illness that
would prevent the subject from signing the informed consent form.
- 2. Pregnant or breast feeding females.
- 3. Any condition, including the presence of laboratory abnormalities, which places the
subject at unacceptable risk if he/she were to participate in the study or confounds
the ability to interpret data from the study.
- 4. Known hypersensitivity to thalidomide or Lenalidomide.
- 5. The development of erythema nodosum if characterized by a desquamating rash while
taking thalidomide or similar drugs.
- 6. Known seropositive for or active viral infection with human immunodeficiency virus
(HIV), hepatitis B virus (HBV) or hepatitis C virus (HCV). Patients who are
seropositive because of hepatitis B virus vaccine or prior infection to which they are
now immune (i.e., not carriers) are eligible.
Donor Inclusion Criteria:
The following categories of donor will be acceptable:
- 1. HLA-matched related donor (5/6 or 6/6 match): Minimal typing necessary is serologic
typing for class I (A, B) and molecular typing for class II (DRB1).
- 2. HLA-matched Unrelated Donor (MUD): Molecular identity at least at HLA A, B, C, and
DRB1 and DQB1 (8/10 match) by high resolution typing is required.
- 3. Syngeneic donors are not eligible.
- 4. The donor must be healthy and must be an acceptable donor as per institutional
standards for marrow or stem cell donation.
- 5. Age ≥ 18 years
We found this trial at
1
site
535 Barnhill Dr
Indianapolis, Indiana 46202
Indianapolis, Indiana 46202
(888) 600-4822
Indiana University Melvin and Bren Simon Cancer Center At the IU Simon Cancer Center, more...
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