Does Glaucoma Cause Loss of Brain Function?
| Status: | Completed |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 11/22/2018 |
| Start Date: | August 2010 |
| End Date: | August 2013 |
Neuroimaging Brain Changes in Glaucoma
The purpose of the study is to determine if glaucoma is associated with neurodegenerative
changes in areas of the brain other than the occipital lobe. This will help guide the
direction of further research in the use of neuroprotective agents in preventing or
controlling such changes. The final goal is to improve the quality of life for patients with
glaucoma.
changes in areas of the brain other than the occipital lobe. This will help guide the
direction of further research in the use of neuroprotective agents in preventing or
controlling such changes. The final goal is to improve the quality of life for patients with
glaucoma.
Death of retinal ganglion cells causes loss of neurons in areas other than just the visual
cortex. These neurodegenerative changes decrease the patient's ability to perform the
activities of daily living. Tensor-based morphometry analysis of magnetic resonance imaging
(MRI) brain scans will reveal areas of cortical degeneration in glaucoma patients, and the
extent of damage in these areas should correlate with patients ability to perform
vision-dependent tasks, as measured by the Assessment of Ability Related to Vision (AARV).
Patients with glaucoma who were outliers in two previous studies, Assessment of Ability
Related to Vision (AARV) or Assessment of Disability related to vision (ADREV), in that they
had poor performance-based measure scores despite having midrange visual field scores.
Mini-Mental State Exam and T-1 weighted MRI brain scan and will be performed.
cortex. These neurodegenerative changes decrease the patient's ability to perform the
activities of daily living. Tensor-based morphometry analysis of magnetic resonance imaging
(MRI) brain scans will reveal areas of cortical degeneration in glaucoma patients, and the
extent of damage in these areas should correlate with patients ability to perform
vision-dependent tasks, as measured by the Assessment of Ability Related to Vision (AARV).
Patients with glaucoma who were outliers in two previous studies, Assessment of Ability
Related to Vision (AARV) or Assessment of Disability related to vision (ADREV), in that they
had poor performance-based measure scores despite having midrange visual field scores.
Mini-Mental State Exam and T-1 weighted MRI brain scan and will be performed.
Inclusion Criteria:
- Patients with glaucoma who were participated in other studies Assessment of Ability
Related to Vision (AARV) or Assessment of Disability Related to Vision (ADREV) and
were found to be outliers in that they have poor performance-based measure scores (≤
40) despite having midrange visual field scores (mean deviation of -6 to -20).
- Age-, gender- and race-matched controls who do not have glaucoma, and who do not have
loss of vision for any reason other than cataract or refractive error.
Exclusion Criteria:
1. Patients with any type of neurological disease.
2. Patients with a cognitive deficit which would affect visual functioning, as revealed
by score of less than 25 in the mini mental status examination.
We found this trial at
1
site
Click here to add this to my saved trials
