Muscle Atrophy, Physical Performance and Glucose Tolerance Post Stroke

The vast majority of cerebrovascular accidents are reported in persons older than 55 years of
age and occur in over 780,000 persons each year in the U.S. As our adult population ages, the
number of strokes in the United States is anticipated to double, reaching nearly 1.5 million
annually by the year 2050. Following stroke, patients remain at continued high risk for
recurrent stroke with almost a third of them suffering recurrent stroke within 5 years, even
despite optimal medical management. Age and cardiac disease are among the most important
longitudinal predictors of cardiovascular health outcomes and survival after stroke. Notably,
75% of chronic stroke survivors have residual disability emphasizing the need for
rehabilitation strategies.

Knowledge of the skeletal muscle changes that occur in the early phases after stroke is
essential to create new guidelines which incorporate exercise rehabilitation, much like
cardiac rehabilitation, in order to facilitate and improve the health care of stroke
survivors.

Inclusion Criteria:

- Men or women 21 years of age or older

- BMI between 20-50 kg/m2

- Presenting within a month after stroke onset with residual hemiparetic deficit

- Patients must have adequate language and neurocognitive function to participate in
testing and give adequate informed consent

Exclusion Criteria:

- Patients deemed too disabled to participate in physical therapy, or patients with
minimal deficits, or patients who fully recovered after their stroke, in which
physical therapy is not necessary

- Unstable angina, CHF, severe PAD

- Dementia or untreated major depression

- Severe receptive or global aphasia

- Heavy alcohol use defined by greater than 3 oz. liquor, 12 oz of wine or 32 oz of beer
daily

- Muscle biopsy Exclusion Criteria:

- anti-coagulation therapy with heparin, warfarin, or lovenox (anti-platelet
therapy is permitted)

- bleeding disorder

- allergy to lidocaine