Assessment of Endothelial Function, Apolipoproteins and Adiponectin
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 4/21/2016 |
| Start Date: | June 2011 |
| End Date: | April 2016 |
Assessment of Endothelial Function, Apolipoproteins, and Adiponectin Levels as Markers of Cardiovascular Before and After Liver Transplantation
The overall hypothesis is that endothelial function, apolipoprotein levels and adiponectin
levels are accurate predictors of underlying cardiovascular disease in patients with
end-stage liver disease, in whom standard tools for the diagnosis of and screening for
cardiovascular disease are of limited utility.
levels are accurate predictors of underlying cardiovascular disease in patients with
end-stage liver disease, in whom standard tools for the diagnosis of and screening for
cardiovascular disease are of limited utility.
This study is looking at using a noninvasive test called a reactive hyperemia peripheral
artery tonometry (RH-PAT) to check endothelial dysfunction. Endothelial dysfunction is
thought to be an indication of future heart disease or metabolic disorders. Adiponectin is a
hormone associated with heart disease. Apolipoprotein levels, are established risk factors
for coronary artery disease in the general population. Our group would like to see if there
is a link between endothelial function, adiponectin, apolipoprotein levels and
posttransplant heart disease complications. The study would be taking these results to find
new clinical procedures for patients that are at potentially higher risk of heart problems
during and after their liver transplant procedure.
artery tonometry (RH-PAT) to check endothelial dysfunction. Endothelial dysfunction is
thought to be an indication of future heart disease or metabolic disorders. Adiponectin is a
hormone associated with heart disease. Apolipoprotein levels, are established risk factors
for coronary artery disease in the general population. Our group would like to see if there
is a link between endothelial function, adiponectin, apolipoprotein levels and
posttransplant heart disease complications. The study would be taking these results to find
new clinical procedures for patients that are at potentially higher risk of heart problems
during and after their liver transplant procedure.
Inclusion Criteria:
- Greater than or equal to 21 years of age.
- Cirrhotic end-stage liver disease
- Pre-transplant
Exclusion Criteria:
- Dialysis shunt
- non-cirrhotic liver disease
- fulminant hepatic failure
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