Effect of Intrathecal Clonidine in Hypertensive Subjects With Poorly Controlled Blood Pressure
| Status: | Archived |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | February 2011 |
| End Date: | February 2012 |
Hemodynamic Effect of Intrathecal Clonidine in Hypertensive Subjects: A Pilot Study to Assess Its Effectiveness in Hypertensive Subjects With Poor Blood Pressure Control (Phase II)
The purpose of this study is to determine the acute efficacy of intrathecal clonidine to
reduce blood pressure in hypertensive subjects with poor blood pressure control and describe
its effects on cardiovascular function.
Hypertension occurs commonly, is associated with major morbidity and mortality, and responds
poorly to current therapies in a small minority of compliant patients. The goal of this
investigator-initiated study is to determine whether intrathecal administration of clonidine
reduces blood pressure in hypertensive patients, focusing on a group who often achieve
inadequate blood pressure control with multiple drug therapy.
After consent, pts will be screened and if qualified brought into center and intrathecal
injection of clonidine given. Patients will be closely monitored for 4 hours, while data is
collected.
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