The Effects of Emollient Therapy on the Skin Barrier
| Status: | Completed |
|---|---|
| Conditions: | Psoriasis, Skin and Soft Tissue Infections, Dermatology |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/2/2016 |
| Start Date: | January 2011 |
| End Date: | January 2014 |
The Effects of Emollient Therapy on the Skin Barrier Function
The goal of this study is to better understand what effect emollients (moisturizers) have on
the skin in young children and adults.
Subjects will be recruited from PI and Sub-I clinics and Oregon Health & Science University
(OHSU) research opportunities website.
1. Adult and Adolescent Study:
Moisturizer Intervention - There will be 2-3 visits for this study: a screening visit,
a baseline visit, and a final visit. Adults with a history of eczema will be asked to
apply one of four possible moisturizers to one arm and nothing to the other arm for
four weeks. The moisturizers, which will be assigned to the subjects, include either
Cetaphil Cream, Aveeno Eczema Therapy Moisturizing Cream, CeraVe Moisturizing Cream, or
Vaseline 100% Petroleum Jelly. Subjects can use other skin treatments as needed for
their skin condition, but may not treat the arms during the study. Non-invasive tests
of the skin will be made at Visit 1 and after four weeks (Visit 2). The skin
measurements that will be performed are:
- Transepidermal loss (TEWL)- measures how much water is lost across the skin
barrier
- Skin Cohesion and TEWL - TEWL after 5, 10, 15, and 20 tape strips will measure
skin barrier function after tape-stripping
- Skin electrical capacitance - measures the moisture in the top layer of skin
- Skin pH - measures the acidity of the skin
- Stratum corneum cohesion assay - tape-stripping to measure the protein removed
from the top layer of skin
- Lipidomic analysis - measures the lipids, or oils, in the top layer of skin
Control - There will be 1-2 visits for this group: a screening visit and baseline
visit, which can be combined. Non-invasive tests of the skin will be taken and
include the skin measurements that will be performed are the same as the
Moisturizer Intervention group.
2. Pediatric Study: There will be 2-3 visits for this study: a screening visit, a baseline
visit, and a final visit. Infants and toddlers between 3 months and 3 years of age
without a history of skin barrier diseases will be assigned to a moisturizer, which
include either Cetaphil Cream, Aveeno Eczema Therapy Moisturizing Cream, CeraVe
Moisturizing Cream, or Aveeno Skin Relief Moisture Repair Cream. Non-invasive tests of
the skin will be made at Visit 1 and after four weeks (Visit 2).
- TEWL- measures how much water is lost across the skin barrier
- Skin electrical capacitance - measures the moisture in the top layer of skin
- Skin pH - measures the acidity of the skin
the skin in young children and adults.
Subjects will be recruited from PI and Sub-I clinics and Oregon Health & Science University
(OHSU) research opportunities website.
1. Adult and Adolescent Study:
Moisturizer Intervention - There will be 2-3 visits for this study: a screening visit,
a baseline visit, and a final visit. Adults with a history of eczema will be asked to
apply one of four possible moisturizers to one arm and nothing to the other arm for
four weeks. The moisturizers, which will be assigned to the subjects, include either
Cetaphil Cream, Aveeno Eczema Therapy Moisturizing Cream, CeraVe Moisturizing Cream, or
Vaseline 100% Petroleum Jelly. Subjects can use other skin treatments as needed for
their skin condition, but may not treat the arms during the study. Non-invasive tests
of the skin will be made at Visit 1 and after four weeks (Visit 2). The skin
measurements that will be performed are:
- Transepidermal loss (TEWL)- measures how much water is lost across the skin
barrier
- Skin Cohesion and TEWL - TEWL after 5, 10, 15, and 20 tape strips will measure
skin barrier function after tape-stripping
- Skin electrical capacitance - measures the moisture in the top layer of skin
- Skin pH - measures the acidity of the skin
- Stratum corneum cohesion assay - tape-stripping to measure the protein removed
from the top layer of skin
- Lipidomic analysis - measures the lipids, or oils, in the top layer of skin
Control - There will be 1-2 visits for this group: a screening visit and baseline
visit, which can be combined. Non-invasive tests of the skin will be taken and
include the skin measurements that will be performed are the same as the
Moisturizer Intervention group.
2. Pediatric Study: There will be 2-3 visits for this study: a screening visit, a baseline
visit, and a final visit. Infants and toddlers between 3 months and 3 years of age
without a history of skin barrier diseases will be assigned to a moisturizer, which
include either Cetaphil Cream, Aveeno Eczema Therapy Moisturizing Cream, CeraVe
Moisturizing Cream, or Aveeno Skin Relief Moisture Repair Cream. Non-invasive tests of
the skin will be made at Visit 1 and after four weeks (Visit 2).
- TEWL- measures how much water is lost across the skin barrier
- Skin electrical capacitance - measures the moisture in the top layer of skin
- Skin pH - measures the acidity of the skin
1. Pediatric study
- Inclusion Criteria
- Enrollment in the BEEP emollient intervention study (IRB #6083)
- Overall good health
- Exclusion Criteria
- Have a history of or are being evaluated for a skin barrier disease
- Have an active skin infection
- Are receiving phototherapy
- Any immunodeficiency disorder or severe genetic skin disorder
- Any other serious condition that would make the use of emollients
inadvisable
- Any other major medical problems that the investigator deems may increase
the risk of adverse events with the intervention
2. Adult Study
- Inclusion Criteria
- Have a history of atopic dermatitis
- 12 years or older
- 4 x 4 cm of non-lesional skin on both inner forearms
- No other conditions that would make the use of the four emollients harmful
to the subject, such as known allergy to an emollient or a component o the
emollient
- Exclusion Criteria
- Use of topical steroids on the inner forearms or oral immunosuppressive
medications for 4 weeks prior to participation in the study.
- Receiving phototherapy or systemic immunosuppressive therapy three months
prior to participation in the study.
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