Use of AEEG as Predictor of Long-term Motor Outcome in Neonates With Congenital Heart Disease
| Status: | Archived |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | July 2010 |
| End Date: | December 2011 |
This study aims to examine performance on a neurological screening test, the Dubowitz, and
sleep wake cycles on amplitude integrated electroencephalogram (AEEG) in neonates with
congenital heart disease (CHD) as a way to potentially predict longterm motor outcome. It
will compare the results of these studies to neonates without CHD.
Neonates with congenital heart disease are at increased risk of adverse long term
neurodevelopmental outcomes, including lower mean intelligent quotients (IQs). However, it
is difficult to predict with neonates are most likely to be affected and a cost effective
method is needed. AEEG has been used in neonates with hypoxic-ischemic encephalopathy and
abnormal sleep wake cycles have been proposed to predict poorer long term outcomes. We thus
hypothesize that abnormal sleep wake cycles in neonates with congenital heart disease will
correlate with poorer outcomes. In our study, we will examine the relationship between
performance on a neurodevelopmental screening tool, the Dubowitz neonatal neurological
screening tool, and the sleep wake cycles on AEEG both before and after cardiac repair to
try and predict which neonates are at increased risk of adverse long term outcomes. We will
also compare the findings of the AEEG and performance on the neurodevelopmental tool to the
data gathered from neonates without cardiac disease.
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