Anti-TGF-beta Therapy in Patients With Myelofibrosis
| Status: | Archived |
|---|---|
| Conditions: | Cancer, Blood Cancer, Hematology |
| Therapuetic Areas: | Hematology, Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | February 2011 |
Phase I Study of GC1008 in Patients With Primary Myelofibrosis (PMF), Post-polycythemia Vera/Essential Thrombocythemia Related Myelofibrosis (Post-PV/ET MF)
TGF-β is a cytokine that is found to be upregulated in the bone marrow of patients with
myelofibrosis. This cytokine likely plays a dual role in promoting myelofibrosis and
myeloproliferation, both of which are the bone marrow morphologic hallmark of MF. The
investigators propose that inhibiting the TGF-β signaling pathway in MF will decrease the
fibrogenic stimuli leading to myelofibrosis and concomitantly interrupt myeloproliferation.
This is a noverl approach to the treatment of patients with myelofibrosis.
We found this trial at
2
sites
Mayo Clinic Scottsdale Mayo Clinic Arizona was the second Mayo practice to be established outside...
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Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
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