The Potential Effects of Inofolic Plus on Abnormal Ovarian Reserve Parameters in Subfertile Women

Inofolic Plus® contains several nutritional elements including myo-inositol, melatonin, and
folic acid. Myo-inositol was found to be helpful in improving egg quality and/or quantity in
women with an ovarian abnormality called polycystic ovarian syndrome as well as in women
without the disorder undergoing assisted reproduction.

Myo-inositol and folic acid are compounds that belong to the family of B-vitamins. Inositol
is normally found in several types of foods. Folic acid has been found to significantly
decrease the incidence of certain types of birth defects in women taking sufficient amounts
prior to and during pregnancy. Preliminary studies using myo-inositol and folic acid
demonstrated improvement in egg quality in-vitro and in-vivo as well as multiple metabolic
parameters in women with irregular menstrual cycles and certain types of hormone imbalances.

Melatonin is a potent antioxidant. Folic acid is not classified as an antioxidant but has
been reported to have antioxidant-like activity. Antioxidants have been given to infertile
men for years to improve egg parameters. Most recently, studies have documented the efficacy
of antioxidant treatment on human egg parameters and fertilization rates, especially in the
setting of in-vitro fertilization (IVF). Inofolic Plus® contains melatonin and folic acid.
Dr. Roseff hypothesizes that Inofolic Plus® may be effective in correcting abnormal egg
parameters in women. A woman may have abnormal eggs from being exposed to environmental and
workplace toxins that generate oxygen free radicals in her body (known as reactive oxygen
species, or ROS). These ROS circulate through the blood stream and can enter the ovaries
where eggs are stored. Eggs may be sensitive to ROS, and damage from the ROS may result in
poor egg quality or quantity or both. The combination of nutrients and antioxidants in
Inofolic Plus® may help to correct these abnormalities. Melatonin is a natural hormone
normally found in the brain. This hormone helps regulate sleep/wake cycles. Melatonin levels
increase during the evening and remain high during the night. This elevated level of
melatonin is thought to induce drowsiness. It is because of this effect that we recommend
taking Inofolic Plus® in the late evening near bedtime.