BPA Biomonitoring Study in Cashiers

We intend to conduct a pilot study designed to measure BPA levels before and after
occupational exposure to thermal paper used in cash registers. We will recruit cashiers from
a local commercial store that is currently still using BPA-laden thermal paper and plans to
switch to BPA-free paper in the near future. The study uses a within-subject comparison
design, using serum and urine samples to determine whether BPA is detectable in the study
population at sufficient levels to measure differences in paired samples. Two phases of
sample collection are proposed: Phase I - collecting paired samples on two separate
occasions before the implementation of BPA-free thermal paper use in cash registers; and
Phase II - collecting paired samples on two separate occasions after the implementation of
this change in thermal paper.

- INCLUSION CRITERIA:

- Male or female 18 years of age or older at the time of enrollment

- Employed as a cashier at the site location

- Anticipate continued employment at this business for the duration of both phases of
the study

- Able to understand and provide written informed consent to participate in the study

- Have a minimum of 24 hours off from work before providing pre-shift samples

- Participants may be healthy or have preexisting conditions.

Field Site Inclusion Criteria:

- Have a minimum of 20 employed cashiers

- Use BPA-laden thermal paper and is planning to switch to BPA-free thermal paper

- Have a private area that the study nurse can use for enrollment and collection of
biological samples

- Willing to collaborate with study team to conduct study on-site

EXCLUSION CRITERIA:

-There are no additional exclusion criteria