Observational Study of Blood Pressure Measurements and Continuous Dialysis
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Hospital, Pulmonary |
| Therapuetic Areas: | Nephrology / Urology, Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | February 2011 |
| End Date: | June 2015 |
| Contact: | Michael O'Connor, MD |
| Email: | moc5@dacc.uchicago.edu |
| Phone: | (773) 702-0182 |
Observational Study Evaluating the Hemodynamic Relationship Between Volume Removal and Pulse Pressure Variation During Renal Replacement Therapy
Dialysis is used to control the fluid balance and metabolic state of patients with kidney
disease. Control of the metabolic state, via electrolytes, can be monitored using labs that
are routinely drawn from patients undergoing continuous hemodialysis. Control of fluid
removal is much more difficult. This study aims to determine whether changes in the blood
pressure associated with breathing correlate with or predict intolerance to fluid
responsiveness with continuous dialysis.
We hypothesize that a measurement of changes in blood pressure with breathing called
arterial pulse pressure variation may be able to predict the ability to remove fluid during
continuous renal replacement therapy.
disease. Control of the metabolic state, via electrolytes, can be monitored using labs that
are routinely drawn from patients undergoing continuous hemodialysis. Control of fluid
removal is much more difficult. This study aims to determine whether changes in the blood
pressure associated with breathing correlate with or predict intolerance to fluid
responsiveness with continuous dialysis.
We hypothesize that a measurement of changes in blood pressure with breathing called
arterial pulse pressure variation may be able to predict the ability to remove fluid during
continuous renal replacement therapy.
Inclusion Criteria:
- age > 17 years old
- CVVHD renal replacement therapy
- indwelling arterial line
Exclusion Criteria:
- age < 18 years old
- pregnancy
- temperature < 34°C
- severe mechanical ventilator dyssynchrony
- cardiac arrhythmias precluding automated PPV measurement by ICU monitors
- non-pulsatile cardiac flow
- open thoracic cavity
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