Improving the Sleep and Circadian Rhythms of Mechanically Ventilated Patients
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies, Hospital, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/9/2018 |
| Start Date: | January 2011 |
| End Date: | December 2016 |
The goal of this project is to determine whether the sleep and circadian rhythms of
critically ill patients undergoing mechanical ventilation can be improved through practical
strategies that can be employed at the bedside.
critically ill patients undergoing mechanical ventilation can be improved through practical
strategies that can be employed at the bedside.
Nearly 1 million patients develop respiratory failure annually in the United States; yet, the
sleep of patients undergoing mechanical ventilation has received little attention. This
project is designed to characterize sleep and circadian rhythmicity in critically ill
patients and to explore the efficacy of a non-pharmacological intervention to improve sleep
and normalize circadian phase. The study will examine the effect of a protocol employing
noise reduction and enforcement of a robust light-dark cycle on sleep quality and circadian
rhythmicity. A secondary analysis will examine the relationship between delirium and sleep
disruption and loss of circadian rhythmicity. Circadian rhythmicity will be characterized
through the measurement of urinary 6-sulfatoxymelatonin levels at frequent intervals, while
sleep will be assessed using continuous polysomnography.
sleep of patients undergoing mechanical ventilation has received little attention. This
project is designed to characterize sleep and circadian rhythmicity in critically ill
patients and to explore the efficacy of a non-pharmacological intervention to improve sleep
and normalize circadian phase. The study will examine the effect of a protocol employing
noise reduction and enforcement of a robust light-dark cycle on sleep quality and circadian
rhythmicity. A secondary analysis will examine the relationship between delirium and sleep
disruption and loss of circadian rhythmicity. Circadian rhythmicity will be characterized
through the measurement of urinary 6-sulfatoxymelatonin levels at frequent intervals, while
sleep will be assessed using continuous polysomnography.
Inclusion Criteria:
- Age 18 years or older
- Receiving mechanical ventilation and intravenous sedation
Exclusion Criteria:
- Debilitating central nervous system disease or degenerative disorder
- Active seizures
- Persistent coma
- Renal failure requiring dialysis
- Expected to be extubated within 24 hours
- Currently receiving neuromuscular blocker
We found this trial at
2
sites
University of Iowa Hospitals and Clinics University of Iowa Hospitals and Clinics—recognized as one of...
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University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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