Blood/Interstitial Glucose Measurements and Cognitive Function During Hypoglycemia and Recovery



Status:Completed
Conditions:Cognitive Studies, Other Indications, Endocrine
Therapuetic Areas:Endocrinology, Psychiatry / Psychology, Other
Healthy:No
Age Range:18 - 50
Updated:4/2/2016
Start Date:January 2011
End Date:October 2015
Contact:Astrid Atakov Castillo, BA
Email:Astrid.Atakov-Castillo@joslin.harvard.edu
Phone:617-309-1997

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Trial Summary
Trial Overview
Inclusion Criteria
The purpose of this study is to find out the effects of hypoglycemia on cognition in healthy
individuals and how well changes in (interstitial) tissue glucose levels correlate with
changes in cognitive function as compared to blood glucose levels.

Subjects will undergo hypoglycemic clamps during which interstitial glucose will be measured
and cognitive function will be assessed.

Inclusion Criteria:

- non obese (BMI <30), ages 18-50

Exclusion Criteria:

- renal or hepatic failure

- cancer or lymphoma

- malabsorption or malnourishment

- hypercortisolism

- alcoholism or drug abuse

- anemia

- eating disorder or depression

- coronary artery disease

- Arrhythmias

- hypertension

- on medications known to affect the blood glucose to be measured such as

- glucocorticoids

- on blood thinning agents

- Pregnant women, breastfeeding women and women who want to become pregnant in the
next 6 months will be excluded from the study.

- Subjects who have donated blood two weeks prior to the study.

- Allergies to pig derived products (Heparin will be used)
We found this trial at
1
site
Joslin Diabetes Center
One Joslin Place
Boston, Massachusetts 02215
617-309-2400
Joslin Diabetes Center Joslin Diabetes Center, located in Boston, Massachusetts, is the world's largest diabetes...
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