Veliparib in Combination With Carboplatin and Paclitaxel in Treating Patients With Locally Advanced or Metastatic Solid Tumors

PRIMARY OBJECTIVE:

I. To determine the maximum-tolerated dose (MTD) of the combination of weekly carboplatin,
paclitaxel, and veliparib.

SECONDARY OBJECTIVES:

I. To assess the safety, tolerability, and MTD of the combination of weekly carboplatin,
paclitaxel, and veliparib.

II. To assess the safety and toxicity of this combination as determined by the Common
Terminology Criteria for Adverse Events version 4.0 (CTCAE v. 4.0) and to determine the
dose-limiting toxicity (DLT).

III. To determine the pharmacokinetic and pharmacodynamic effects of this combination,
including determinations of poly (adenosine diphosphate [ADP]-ribose) polymerase (PAR) in
tumor specimens when available, assessment of deoxyribonucleic acid (DNA) damage as measured
by gamma H2A histone family, member X (g-H2AX) in skin biopsies and tumor specimens will be
obtained.

IV. To assess characteristics of primary tumor specimens that may contribute to efficacy of
this combination including breast cancer, early onset (BRCA) by immunohistochemistry, gene
analysis of PARP 1, PARP 2, BRCA, and triple negative and homologous recombination repair
(HRR) deficiency gene expression signatures.

V. To document any anti-tumor response.

OUTLINE: This is a dose-escalation study of veliparib.

DOSE-ESCALATION: Patients receive veliparib orally (PO) twice daily (BID) on days 1-5, 8-12,
and 15-19 and paclitaxel IV over 1 hour and carboplatin IV over 30 minutes in course 1 and 3
hours in subsequent courses on days 3, 10, and 17. After 4 courses, patients receive
paclitaxel and carboplatin on days 3 and 10 only. Courses repeat every 21 days in the
absence of disease progression or unacceptable toxicity. (Completed as of 12/2012)

EXPANSION COHORT: Patients receive veliparib PO BID on days 1-21 and paclitaxel IV over 1
hour and carboplatin IV over 3 hours on days 3 and 10. Courses repeat every 21 days in the
absence of disease progression or unacceptable toxicity.

After completion of study therapy, patients are followed up for 4 weeks.

Inclusion Criteria:

- Histologically or cytologically confirmed solid tumor that has evidence of metastatic
spread (stage IV) or is locally advanced and unresectable

- Patients with breast cancer may have estrogen receptor positive or negative (ER+
or ER-) disease

- Patients with breast cancer may not be human epidermal growth receptor -2
(HER2)-positive ( 3+), or fluorescent in situ hybridization (FISH) ratio > 2.2

- Patients in the biopsy expansion cohort must have "triple negative" breast
cancer defined as:

- Estrogen receptor staining < 10%; progesterone receptor staining <10%; Her
2 < 2.2 by FISH, or immunohistochemistry (IHC) 0-2+

- Patients may have been previously treated

- In the dose escalation cohort, there is no limit to prior therapies

- In the expansion cohort, patients may have only had 1-3 prior regimens for
metastatic disease

- Patients may have received prior carboplatin, paclitaxel, or poly (ADP-ribose)
polymerase (PARP) inhibitor therapy as part of their previous treatment regimens

- However, patients may NOT have received prior therapy with paclitaxel,
carboplatin, and PARP inhibitor in combination

- Patients must not have received chemotherapy within 4 weeks of starting study
(or 6 weeks if prior treatment was with carmustine [BCNU] or mitomycin C)

- Patients must not have received radiation within 2 weeks of starting study

- Eastern Cooperative Oncology Group (ECOG) performance status (PS)< 2 (Karnofsky >
60%)

- Life expectancy > 2 months

- Absolute neutrophil count (ANC) >= 1,500/mcL

- Platelet count >= 100,000/mcL

- Total bilirubin =< 1.5 times upper limit of normal (ULN)

- Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase
[SGOT]/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT])
=< 2.5 times ULN

- Creatinine normal within normal institutional limits OR creatinine clearance >= 60
mL/min/1.73m^2 for patients with creatinine levels above institutional normal

- Must able to swallow pills

- Pregnant women are excluded from this study

- Women of child-bearing potential and men must agree to use adequate
contraception (hormonal or barrier method of birth control; abstinence) prior to
study entry and for the duration of study participation; should a woman become
pregnant or suspect she is pregnant while participating in this study, she
should inform her treating physician immediately

- Ability to understand and the willingness to sign a written informed consent document

- Patients enrolled in the expanded cohort with mandatory biopsies must:

- Have accessible tumors

- Not be on therapeutic anticoagulation

- Have signed informed consent form

Exclusion Criteria:

- Patients who have had chemotherapy within 4 weeks (6 weeks for nitrosoureas or
mitomycin C) or radiotherapy within 2 weeks (4 weeks for central nervous system [CNS]
metastases) prior to entering the study or those who have not recovered from adverse
events due to agents administered more than 4 weeks earlier

- Patients may not be receiving any other investigational agents

- History of allergic reactions attributed to compounds of similar chemical or biologic
composition to veliparib or other agents used in study

- Concurrent treatment with bisphosphonates, or other bone anti-resorptive agent such
as denosumab is allowed; concurrent treatment with hormonal therapy (tamoxifen,
ovarian suppression with gonadotropin-releasing hormone [GNRH] agonists, aromatase
inhibitors) or trastuzumab therapy is NOT allowed in breast cancer patients; prostate
cancer patients may continue GNRH agents

- Uncontrolled intercurrent illness including, but not limited to, ongoing or active
infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac
arrhythmia, or psychiatric illness/social situations that would limit compliance with
study requirements

- Pregnant women are excluded from this study; breastfeeding should be discontinued if
the mother is treated with veliparib

- Active seizure or history of seizure disorder

- Patients with CNS metastases must be stable after therapy for CNS metastases (such as
surgery, radiotherapy or stereotactic radiosurgery) for > 3 months and must be off
steroid treatment prior to study enrollment

- Patients who undergo biopsy as part of the study in the expanded dose cohort should
not be on anti-coagulants or have a pre-existing coagulopathy

- Peripheral neuropathy of severity greater than grade 1