Cervical Foley Plus Vaginal Misoprostol for Labor Induction
| Status: | Completed |
|---|---|
| Conditions: | Women's Studies |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | 16 - 45 |
| Updated: | 1/10/2019 |
| Start Date: | January 2011 |
| End Date: | March 2014 |
Cervical Foley Plus Vaginal Misoprostol Versus Vaginal Misoprostol for Cervical Ripening and Labor Induction: A Randomized Trial
The purpose of this study is to compare the efficacy of the combination of the supracervical
foley bulb and vaginal misoprostol to vaginal misoprostol alone for labor induction. We
hypothesize that use of the foley bulb plus vaginal misoprostol will result in shorter
induction to delivery time.
foley bulb and vaginal misoprostol to vaginal misoprostol alone for labor induction. We
hypothesize that use of the foley bulb plus vaginal misoprostol will result in shorter
induction to delivery time.
More than 22% of all gravid women undergo induction of labor in the United States for various
indications. Although there are several techniques and methods for induction of labor, the
best agent and method still remains uncertain. To date, there has been no randomized trial
comparing foley bulb plus vaginal misoprostol versus vaginal misoprostol alone. The
combination of a mechanical device (foley bulb) and synthetic prostaglandin may have an
additive or synergistic effect, resulting in greater degree of cervical ripening and shorter
induction to delivery time (IDT). The addition of a synthetic prostaglandin to the foley bulb
may also overcome the frequent observation of cervical dilation to 4cm by the foley bulb
without effacement.
indications. Although there are several techniques and methods for induction of labor, the
best agent and method still remains uncertain. To date, there has been no randomized trial
comparing foley bulb plus vaginal misoprostol versus vaginal misoprostol alone. The
combination of a mechanical device (foley bulb) and synthetic prostaglandin may have an
additive or synergistic effect, resulting in greater degree of cervical ripening and shorter
induction to delivery time (IDT). The addition of a synthetic prostaglandin to the foley bulb
may also overcome the frequent observation of cervical dilation to 4cm by the foley bulb
without effacement.
Inclusion Criteria:
- singleton pregnancy
- vertex presentation
- unfavorable cervix(Bishop's score less than or equal to 6)
- greater than 24 weeks gestation
Exclusion Criteria:
- fetal malpresentation
- multifetal gestation
- spontaneous labor
- more than 5 uterine contractions in 10 minutes
- contraindication to prostaglandins
- non-reassuring fetal heart rate tracing
- intrauterine growth restriction
- anomalous fetus
- fetal demise
- previous cesarean delivery or other significant uterine surgery
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