A Dose-escalation Pharmacokinetic Study of Intravenous ASA404 in Adult Advanced Cancer Patients With Impaired Renal Function and Patients With Normal Renal Function



Status:Archived
Conditions:Cancer, Cancer, Renal Impairment / Chronic Kidney Disease
Therapuetic Areas:Nephrology / Urology, Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:March 2010

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Trial Summary
Trial Overview
Inclusion Criteria

A Multi-center, Open-label, Dose-escalation Study to Assess the Pharmacokinetics of Intravenous ASA404 in Adult Advanced Cancer Patients With Impaired Renal Function and With Normal Renal Function


The purpose of this study is to evaluate the safety and pharmacokinetics of ASA404 in
patients with refractory or relapsed metastatic cancer with impaired renal function and with
normal renal function. It is very possible that patients with renal impairment will show
differences in renal excretion of parent ASA404 and its metabolites, warranting a study that
leads to a better pharmacokinetic assesssment in this population.



We found this trial at
4
sites
Indiana University Melvin and Bren Simon Cancer Center, Hematology/Oncology Dept.
Indiannapolis, Indiana 46202
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Indiannapolis, IN
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Seattle Cancer Care Alliance
825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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Seattle, WA
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Josephine Ford Cancer Center at Henry Ford Hospital
2799 W Grand Blvd
Detroit, Michigan 48202
(888) 777-4167
Josephine Ford Cancer Center at Henry Ford Hospital A diagnosis of cancer is one of...
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Detroit, MI
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Hematology /Oncology Associates
Rockville, Maryland 20850
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Rockville, MD
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