Effect of Aspirin on Hemostatic and Vascular Function After Live Fire Fighting
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 40 - 60 |
| Updated: | 3/1/2014 |
| Start Date: | February 2011 |
| End Date: | June 2013 |
| Contact: | Gavin P Horn, PhD |
| Email: | ghorn@fsi.illinois.edu |
| Phone: | 217-265-6563 |
The investigators hypothesize that
1. an acute treatment of low-dose aspirin will lead to a) decreased resting platelet
activation, platelet aggregation, and clotting potential, b) increased fibrinolytic
potential following fire fighting, c) no significant effect on endothelial function or
arterial stiffness versus the placebo condition.
2. chronic treatment with low-dose aspirin will lead to a) decreased resting and fire
fighting induced platelet activation, platelet aggregation, clotting potential, b)
increased fibrinolytic potential, and c) increased endothelial function and decreased
arterial stiffness in response to live fire fighting versus the placebo condition.
3. short-term fire fighting activity will result in: a) a reduction in arterial function
(reduced endothelial function, increased augmentation index and an attenuated arterial
stiffness response); b) a disruption in hemostasis that is characterized by an increase
in platelet number and function, an increased coagulatory potential and altered
fibrinolytic potential; and c) an elevation in procoagulatory cytokines, systemic
inflammation, monokine chemoattractant protein, and matrix metalloproteinases.
1. an acute treatment of low-dose aspirin will lead to a) decreased resting platelet
activation, platelet aggregation, and clotting potential, b) increased fibrinolytic
potential following fire fighting, c) no significant effect on endothelial function or
arterial stiffness versus the placebo condition.
2. chronic treatment with low-dose aspirin will lead to a) decreased resting and fire
fighting induced platelet activation, platelet aggregation, clotting potential, b)
increased fibrinolytic potential, and c) increased endothelial function and decreased
arterial stiffness in response to live fire fighting versus the placebo condition.
3. short-term fire fighting activity will result in: a) a reduction in arterial function
(reduced endothelial function, increased augmentation index and an attenuated arterial
stiffness response); b) a disruption in hemostasis that is characterized by an increase
in platelet number and function, an increased coagulatory potential and altered
fibrinolytic potential; and c) an elevation in procoagulatory cytokines, systemic
inflammation, monokine chemoattractant protein, and matrix metalloproteinases.
Inclusion Criteria:
- Male firefighters (career and volunteer), medically cleared by home fire department.
- Ages 40 - 60
- Completion of a yearly period medical evaluation based on NFPA 1582 within the past
12 months or an evaluation by an occupational medical group through this study.
Exclusion Criteria:
- Over 60 or under 40 years of age.
- Not a firefighter.
- Individuals at risk for developing gastrointestinal (GI) complications while on
aspirin therapy due to a combination of the following: smoking; concurrent NSAID,
steroid, Clopidogrel, or Warfarin therapy; history of upper GI complications; history
of renal impairment; history of elevated serum creatinine; hypertension; and cardiac
failure.
- Individuals with cases of allergy or asthma, intolerance, and recurrent vascular
events.
- Individuals taking statins.
- Individuals who are currently taking aspiring regularly.
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