Sleep and Circadian Rhythms in Mechanically Ventilated Patients
| Status: | Completed |
|---|---|
| Conditions: | Hospital, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/28/2017 |
| Start Date: | November 2001 |
| End Date: | December 2008 |
Sleep and Circadian Rhythms in Mechanically Ventilated Patients: a Feasibility and Mechanistic Study.
This study examines the feasibility of assessing sleep and circadian rhythmicity in
critically ill patients undergoing mechanical ventilation. Secondarily, it will examine the
feasibility of reducing subject exposure to environmental light and noise and of delivering
routine care according to classical day/night routines.
critically ill patients undergoing mechanical ventilation. Secondarily, it will examine the
feasibility of reducing subject exposure to environmental light and noise and of delivering
routine care according to classical day/night routines.
Over 1 million patients develop respiratory failure annually in the United States; yet, the
sleep of patients undergoing mechanical ventilation has received little attention. This
protocol enrolls acutely ill medical patients undergoing mechanical ventilation. The
feasibility of assessing sleep and circadian rhythmicity through the use of continuous
bedside polysomnography and the measurement of core body temperature and urinary hormonal
levels at frequent intervals will be explored. As a secondary goal, the feasibility of
delivering routine care according to classical day/night routines, and of employing various
noise and light reduction strategies at night, will be explored in a subset of subjects.
sleep of patients undergoing mechanical ventilation has received little attention. This
protocol enrolls acutely ill medical patients undergoing mechanical ventilation. The
feasibility of assessing sleep and circadian rhythmicity through the use of continuous
bedside polysomnography and the measurement of core body temperature and urinary hormonal
levels at frequent intervals will be explored. As a secondary goal, the feasibility of
delivering routine care according to classical day/night routines, and of employing various
noise and light reduction strategies at night, will be explored in a subset of subjects.
Inclusion Criteria:
- Adults undergoing mechanical ventilation in the medical intensive care unit.
Exclusion Criteria:
- Central nervous system disease (stroke, seizure, dementia, etc)
- Metabolic or hypoxic encephalopathy
- Confirmed or suspected drug overdose
- Currently receiving neuromuscular blockers
- Coma
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