Study To Test Whether PF-00547659 Is Safe And Improves Disease Symptoms In Patients With Crohn's Disease



Status:Completed
Conditions:Gastrointestinal, Crohns Disease
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - 75
Updated:10/14/2017
Start Date:April 6, 2011
End Date:October 9, 2015

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Trial Summary
Trial Overview
Inclusion Criteria

A Double-blind, Randomized, Placebo-controlled, Dose-ranging Study To Evaluate The Efficacy And Safety Of Pf-00547659 In Subjects With Crohn's Disease (Opera)

Adults with Crohn's disease that is clinically active despite conventional treatment will be
eligible for this study. Patients may receive one of three doses of PF-00547659 (experimental
drug) or placebo (inactive drug). Disease activity will be measured every two weeks.


Inclusion Criteria:

- Subjects must have failed or are intolerant to anti-TNFs and/or immunosuppressants
(AZA, 6-MP, and/or MTX).

- hsCRP greater than 3mg/L

- Ulcerations demonstrated by colonoscopy performed during screening or 8 weeks prior to
screening

Exclusion Criteria:

- Pregnant or breast feeding

- Short bowel syndrome due to multiple small bowel resections

- Presence of a stoma
We found this trial at
71
sites
North Shore Primary Care, P.C.
Great Neck, New York 11021
1301
mi
from
Great Neck, NY
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Shands Hospital at the University of Florida
Gainesville, Florida 32610
1047
mi
from
Gainesville, FL
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University of Miami
Miami, Florida 33124
(305) 284-2211
University of Miami A private research university with more than 15,000 students from around the...
1319
mi
from
Miami, FL
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Internal Medicine Specialists
Orlando, Florida 32806
1143
mi
from
Orlando, FL
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Albany Medical College
47 New Scotland Ave
Albany, New York 12208
(518) 262-3125
Albany Medical College Albany Medical Center is northeastern New York's only academic health sciences center...
1309
mi
from
Albany, NY
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Connecticut Clinical Research Foundation
Bristol, Connecticut 06010
1344
mi
from
Bristol, CT
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Life Medi-Research and Management
Brooklyn, New York 11206
1287
mi
from
Brooklyn, NY
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North Carolina Memorial Hospital Endoscopy Center
Chapel Hill, North Carolina 27514
1043
mi
from
Chapel Hill, NC
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CTRC Hospital - UNC Memorial Hospital
Chapel Hill, North Carolina 27514
843
mi
from
Chapel Hill, NC
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UNC Hospitals Department of Pharmacy
Chapel Hill, North Carolina 27514
1043
mi
from
Chapel Hill, NC
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UNC Hospitals Endoscopy
Chapel Hill, North Carolina 27517
1043
mi
from
Chapel Hill, NC
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Charlottesville Medical Research Inc.
Charlottesville, Virginia 22911
1055
mi
from
Charlottesville, VA
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Charlottesville Gastroenterology Associates
Charlottesville, Virginia 22902
1053
mi
from
Charlottesville, VA
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Metropolitan Gastroenterology Group, PC Chevy Chase Clinical Research
Chevy Chase, Maryland 20815
1124
mi
from
Chevy Chase, MD
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Iowa Digestive Disease Center
Clive, Iowa 50325
342
mi
from
Clive, IA
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Heartland Medical Research, Inc (Administrative Only)
Clive, Iowa 50325
342
mi
from
Clive, IA
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Iowa Endoscopy Center (Colonoscopy Only)
Clive, Iowa 50325
342
mi
from
Clive, IA
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Surgery Center of Columbia
Columbia, Missouri 65201
308
mi
from
Columbia, MO
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Pharma Resource
East Providence, Rhode Island 02915
1425
mi
from
East Providence, RI
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The Offices of Dr. Vincent Armenio, M.D.
East Providence, Rhode Island 02914
1426
mi
from
East Providence, RI
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New York Hospital- Queens
Flushing, New York 11355
1296
mi
from
Flushing, NY
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Shands Endoscopy Center
Gainesville, Florida 32608
1049
mi
from
Gainesville, FL
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Shands Medical Plaza
Gainesville, Florida 32608
1049
mi
from
Gainesville, FL
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Long Island Clinical Research Associates, LLP
Great Neck, New York 11021
1301
mi
from
Great Neck, NY
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Nassau Gastroenterology Associates, PC
Great Neck, New York 11021
1301
mi
from
Great Neck, NY
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Nassau Gastroenterology Associates, PC
Great Neck, New York 11021
1301
mi
from
Great Neck, NY
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Nassau Gastroenterology Associates Office Based Surgery
Great Neck, New York 11021
1301
mi
from
Great Neck, NY
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Hillsborough Campus
Hillsborough, North Carolina 27278
1038
mi
from
Hillsborough, NC
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Mayo Clinic, Jacksonville
Jacksonville, Florida 32216
1061
mi
from
Jacksonville, FL
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Gastroenterology Specialists of Arkansas
Jonesboro, Arkansas 72401
415
mi
from
Jonesboro, AR
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Clopton Clinic
Jonesboro, Arkansas 72401
415
mi
from
Jonesboro, AR
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UCSD Medical Center, Thornton Hospital
La Jolla, California 92037
1145
mi
from
La Jolla, CA
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Clinical Research of the Rockies
LaFayette, Colorado 80026
421
mi
from
LaFayette, CO
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Florida Center for Gastroenterology
Largo, Florida 33777
1103
mi
from
Largo, FL
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Little Rock Diagnostic Clinic
Little Rock, Arkansas 72205
369
mi
from
Little Rock, AR
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Center for Digestive & Liver Diseases Inc.
Mexico, Missouri 65265
335
mi
from
Mexico, MO
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Audrain Medical Center
Mexico, Missouri 65265
336
mi
from
Mexico, MO
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University of Miami Hospital
1400 NW 12th Ave
Miami, Florida 33136
(305) 689-5511
University of Miami Hospital The University of Miami changed the face of modern health care...
1320
mi
from
Miami, FL
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University of Miami Hospital and Clinic
Miami, Florida 33136
1320
mi
from
Miami, FL
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Sylvester Comprehensive Cancer Center
Miami, Florida 33136
1320
mi
from
Miami, FL
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Minneapolis Heart Institute, West Health Campus
Minneapolis, Minnesota 55404
551
mi
from
Minneapolis, MN
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Noran Neurology Clinic
Minneapolis, Minnesota 55407
550
mi
from
Minneapolis, MN
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Nashville Medical Research Institute
Nashville, Tennessee 37205
615
mi
from
Nashville, TN
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Beth Israel Medical Center - Phillip Ambulatory Care Center
New York, New York 10003
1225
mi
from
New York, NY
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Lenox Hill Endoscopy Center
New York, New York 10075
1289
mi
from
New York, NY
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East side Endoscopy, LLC (for colonscopy testing only)
New York, New York 10010
1225
mi
from
New York, NY
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Community Clinical Trials
Orange, California 92868
1154
mi
from
Orange, CA
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Gastro Diagnostics
Orange, California 92868
1153
mi
from
Orange, CA
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Cirtus Ambulartory Surgery Center
Orlando, Florida 32806
1141
mi
from
Orlando, FL
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Pasadena Gastroenterology Associates, P.A. dba Digestive Health Center
Pasadena, Texas 77505
576
mi
from
Pasadena, TX
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Thomas Jefferson University Hospital
111 S 11th St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
1225
mi
from
Philadelphia, PA
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Minnesota Gastroenterology, P.A.
Plymouth, Minnesota 55446
551
mi
from
Plymouth, MN
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Consulting Radiology (Xray testing only)
Plymouth, Minnesota 55446
551
mi
from
Plymouth, MN
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Premier Medical Group of the Hudson Valley
243 N Rd
Poughkeepsie, New York 12601
(845) 471-9410
Premier Medical Group of the Hudson Valley Premier Medical Group offers comprehensive, integrated care providing...
1294
mi
from
Poughkeepsie, NY
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Bayside Endoscopy Center
Providence, Rhode Island 02905
1424
mi
from
Providence, RI
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Inland Gastroenterology Medical Associates
Redlands, California 92374
1110
mi
from
Redlands, CA
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The Mayo Clinic
Rochester, Minnesota 55905
515
mi
from
Rochester, MN
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
414
mi
from
Saint Louis, MO
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University of Utah HSC
Salt Lake City, Utah 84132
777
mi
from
Salt Lake City, UT
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University of Washington Medical Center
1959 NE Pacific St
Seattle, Washington 98195
(206) 598-3300
University of Washington Medical Center University of Washington Medical Center is one of the nation's...
1410
mi
from
Seattle, WA
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Barnes-Jewish Hospital (Investigational Drug Services)
St. Louis, Missouri 63108
415
mi
from
St. Louis, MO
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Center for Advanced Medicine
St. Louis, Missouri 63110
415
mi
from
St. Louis, MO
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Rocky Mountain Gastroenterology Associates
Thornton, Colorado 80229
410
mi
from
Thornton, CO
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Center for Digestive Health
Troy, Michigan 48098
842
mi
from
Troy, MI
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Surgical Centers of Michigan
Troy, Michigan 48098
841
mi
from
Troy, MI
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Allegiance Research Specialists
Wauwatosa, Wisconsin 53226
632
mi
from
Wauwatosa, WI
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GI Associates
Wauwatosa, Wisconsin 53226
630
mi
from
Wauwatosa, WI
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BioMark Research Inc.
Whittier, California 90603
1157
mi
from
Whittier, CA
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AKH Wien Universitaetsklinik fuer Innere Medizin III
Wien, 1090
5255
mi
from
Wien,
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University of Massachusetts Worcester
Worcester, Massachusetts 01655
1405
mi
from
Worcester, MA
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UMASS Memorial Medical Center
Worcester, Massachusetts 01605
1406
mi
from
Worcester, MA
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