Study To Test Whether PF-00547659 Is Safe And Improves Disease Symptoms In Patients With Crohn's Disease



Status:Completed
Conditions:Gastrointestinal, Crohns Disease
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - 75
Updated:10/14/2017
Start Date:April 6, 2011
End Date:October 9, 2015

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Trial Summary
Trial Overview
Inclusion Criteria

A Double-blind, Randomized, Placebo-controlled, Dose-ranging Study To Evaluate The Efficacy And Safety Of Pf-00547659 In Subjects With Crohn's Disease (Opera)

Adults with Crohn's disease that is clinically active despite conventional treatment will be
eligible for this study. Patients may receive one of three doses of PF-00547659 (experimental
drug) or placebo (inactive drug). Disease activity will be measured every two weeks.


Inclusion Criteria:

- Subjects must have failed or are intolerant to anti-TNFs and/or immunosuppressants
(AZA, 6-MP, and/or MTX).

- hsCRP greater than 3mg/L

- Ulcerations demonstrated by colonoscopy performed during screening or 8 weeks prior to
screening

Exclusion Criteria:

- Pregnant or breast feeding

- Short bowel syndrome due to multiple small bowel resections

- Presence of a stoma
We found this trial at
71
sites
UMASS Memorial Medical Center
Worcester, Massachusetts 01605
605
mi
from 43215
Worcester, MA
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Shands Hospital at the University of Florida
Gainesville, Florida 32610
711
mi
from 43215
Gainesville, FL
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University of Miami
Miami, Florida 33124
(305) 284-2211
University of Miami A private research university with more than 15,000 students from around the...
992
mi
from 43215
Miami, FL
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Internal Medicine Specialists
Orlando, Florida 32806
796
mi
from 43215
Orlando, FL
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Albany Medical College
47 New Scotland Ave
Albany, New York 12208
(518) 262-3125
Albany Medical College Albany Medical Center is northeastern New York's only academic health sciences center...
515
mi
from 43215
Albany, NY
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Connecticut Clinical Research Foundation
Bristol, Connecticut 06010
539
mi
from 43215
Bristol, CT
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Life Medi-Research and Management
Brooklyn, New York 11206
478
mi
from 43215
Brooklyn, NY
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North Carolina Memorial Hospital Endoscopy Center
Chapel Hill, North Carolina 27514
350
mi
from 43215
Chapel Hill, NC
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CTRC Hospital - UNC Memorial Hospital
Chapel Hill, North Carolina 27514
278
mi
from 43215
Chapel Hill, NC
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UNC Hospitals Department of Pharmacy
Chapel Hill, North Carolina 27514
350
mi
from 43215
Chapel Hill, NC
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UNC Hospitals Endoscopy
Chapel Hill, North Carolina 27517
353
mi
from 43215
Chapel Hill, NC
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Charlottesville Medical Research Inc.
Charlottesville, Virginia 22911
279
mi
from 43215
Charlottesville, VA
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Charlottesville Gastroenterology Associates
Charlottesville, Virginia 22902
278
mi
from 43215
Charlottesville, VA
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Metropolitan Gastroenterology Group, PC Chevy Chase Clinical Research
Chevy Chase, Maryland 20815
324
mi
from 43215
Chevy Chase, MD
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Iowa Digestive Disease Center
Clive, Iowa 50325
573
mi
from 43215
Clive, IA
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Heartland Medical Research, Inc (Administrative Only)
Clive, Iowa 50325
573
mi
from 43215
Clive, IA
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Iowa Endoscopy Center (Colonoscopy Only)
Clive, Iowa 50325
573
mi
from 43215
Clive, IA
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Surgery Center of Columbia
Columbia, Missouri 65201
501
mi
from 43215
Columbia, MO
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Pharma Resource
East Providence, Rhode Island 02915
621
mi
from 43215
East Providence, RI
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The Offices of Dr. Vincent Armenio, M.D.
East Providence, Rhode Island 02914
621
mi
from 43215
East Providence, RI
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New York Hospital- Queens
Flushing, New York 11355
487
mi
from 43215
Flushing, NY
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Shands Endoscopy Center
Gainesville, Florida 32608
713
mi
from 43215
Gainesville, FL
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Shands Medical Plaza
Gainesville, Florida 32608
714
mi
from 43215
Gainesville, FL
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Long Island Clinical Research Associates, LLP
Great Neck, New York 11021
492
mi
from 43215
Great Neck, NY
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Nassau Gastroenterology Associates, PC
Great Neck, New York 11021
492
mi
from 43215
Great Neck, NY
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Nassau Gastroenterology Associates, PC
Great Neck, New York 11021
492
mi
from 43215
Great Neck, NY
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North Shore Primary Care, P.C.
Great Neck, New York 11021
492
mi
from 43215
Great Neck, NY
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Nassau Gastroenterology Associates Office Based Surgery
Great Neck, New York 11021
491
mi
from 43215
Great Neck, NY
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Hillsborough Campus
Hillsborough, North Carolina 27278
343
mi
from 43215
Hillsborough, NC
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Mayo Clinic, Jacksonville
Jacksonville, Florida 32216
673
mi
from 43215
Jacksonville, FL
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Gastroenterology Specialists of Arkansas
Jonesboro, Arkansas 72401
506
mi
from 43215
Jonesboro, AR
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Clopton Clinic
Jonesboro, Arkansas 72401
506
mi
from 43215
Jonesboro, AR
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UCSD Medical Center, Thornton Hospital
La Jolla, California 92037
1953
mi
from 43215
La Jolla, CA
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Clinical Research of the Rockies
LaFayette, Colorado 80026
1165
mi
from 43215
LaFayette, CO
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Florida Center for Gastroenterology
Largo, Florida 33777
832
mi
from 43215
Largo, FL
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Little Rock Diagnostic Clinic
Little Rock, Arkansas 72205
624
mi
from 43215
Little Rock, AR
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Center for Digestive & Liver Diseases Inc.
Mexico, Missouri 65265
474
mi
from 43215
Mexico, MO
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Audrain Medical Center
Mexico, Missouri 65265
474
mi
from 43215
Mexico, MO
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University of Miami Hospital
1400 NW 12th Ave
Miami, Florida 33136
(305) 689-5511
University of Miami Hospital The University of Miami changed the face of modern health care...
993
mi
from 43215
Miami, FL
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University of Miami Hospital and Clinic
Miami, Florida 33136
992
mi
from 43215
Miami, FL
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Sylvester Comprehensive Cancer Center
Miami, Florida 33136
992
mi
from 43215
Miami, FL
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Minneapolis Heart Institute, West Health Campus
Minneapolis, Minnesota 55404
624
mi
from 43215
Minneapolis, MN
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Noran Neurology Clinic
Minneapolis, Minnesota 55407
623
mi
from 43215
Minneapolis, MN
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Nashville Medical Research Institute
Nashville, Tennessee 37205
338
mi
from 43215
Nashville, TN
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Beth Israel Medical Center - Phillip Ambulatory Care Center
New York, New York 10003
442
mi
from 43215
New York, NY
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Lenox Hill Endoscopy Center
New York, New York 10075
480
mi
from 43215
New York, NY
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East side Endoscopy, LLC (for colonscopy testing only)
New York, New York 10010
442
mi
from 43215
New York, NY
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Community Clinical Trials
Orange, California 92868
1959
mi
from 43215
Orange, CA
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Gastro Diagnostics
Orange, California 92868
1958
mi
from 43215
Orange, CA
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Cirtus Ambulartory Surgery Center
Orlando, Florida 32806
795
mi
from 43215
Orlando, FL
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Pasadena Gastroenterology Associates, P.A. dba Digestive Health Center
Pasadena, Texas 77505
988
mi
from 43215
Pasadena, TX
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Thomas Jefferson University Hospital
111 S 11th St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
416
mi
from 43215
Philadelphia, PA
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Minnesota Gastroenterology, P.A.
Plymouth, Minnesota 55446
636
mi
from 43215
Plymouth, MN
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Consulting Radiology (Xray testing only)
Plymouth, Minnesota 55446
637
mi
from 43215
Plymouth, MN
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Premier Medical Group of the Hudson Valley
243 N Rd
Poughkeepsie, New York 12601
(845) 471-9410
Premier Medical Group of the Hudson Valley Premier Medical Group offers comprehensive, integrated care providing...
490
mi
from 43215
Poughkeepsie, NY
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Bayside Endoscopy Center
Providence, Rhode Island 02905
619
mi
from 43215
Providence, RI
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Inland Gastroenterology Medical Associates
Redlands, California 92374
1915
mi
from 43215
Redlands, CA
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The Mayo Clinic
Rochester, Minnesota 55905
559
mi
from 43215
Rochester, MN
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
397
mi
from 43215
Saint Louis, MO
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University of Utah HSC
Salt Lake City, Utah 84132
1511
mi
from 43215
Salt Lake City, UT
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University of Washington Medical Center
1959 NE Pacific St
Seattle, Washington 98195
(206) 598-3300
University of Washington Medical Center University of Washington Medical Center is one of the nation's...
2005
mi
from 43215
Seattle, WA
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Barnes-Jewish Hospital (Investigational Drug Services)
St. Louis, Missouri 63108
397
mi
from 43215
St. Louis, MO
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Center for Advanced Medicine
St. Louis, Missouri 63110
397
mi
from 43215
St. Louis, MO
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Rocky Mountain Gastroenterology Associates
Thornton, Colorado 80229
1159
mi
from 43215
Thornton, CO
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Center for Digestive Health
Troy, Michigan 48098
182
mi
from 43215
Troy, MI
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Surgical Centers of Michigan
Troy, Michigan 48098
181
mi
from 43215
Troy, MI
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Allegiance Research Specialists
Wauwatosa, Wisconsin 53226
334
mi
from 43215
Wauwatosa, WI
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GI Associates
Wauwatosa, Wisconsin 53226
335
mi
from 43215
Wauwatosa, WI
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BioMark Research Inc.
Whittier, California 90603
1961
mi
from 43215
Whittier, CA
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AKH Wien Universitaetsklinik fuer Innere Medizin III
Wien, 1090
4607
mi
from 43215
Wien,
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University of Massachusetts Worcester
Worcester, Massachusetts 01655
604
mi
from 43215
Worcester, MA
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