Study To Test Whether PF-00547659 Is Safe And Improves Disease Symptoms In Patients With Crohn's Disease



Status:Completed
Conditions:Gastrointestinal, Crohns Disease
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - 75
Updated:10/14/2017
Start Date:April 6, 2011
End Date:October 9, 2015

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Trial Summary
Trial Overview
Inclusion Criteria

A Double-blind, Randomized, Placebo-controlled, Dose-ranging Study To Evaluate The Efficacy And Safety Of Pf-00547659 In Subjects With Crohn's Disease (Opera)

Adults with Crohn's disease that is clinically active despite conventional treatment will be
eligible for this study. Patients may receive one of three doses of PF-00547659 (experimental
drug) or placebo (inactive drug). Disease activity will be measured every two weeks.


Inclusion Criteria:

- Subjects must have failed or are intolerant to anti-TNFs and/or immunosuppressants
(AZA, 6-MP, and/or MTX).

- hsCRP greater than 3mg/L

- Ulcerations demonstrated by colonoscopy performed during screening or 8 weeks prior to
screening

Exclusion Criteria:

- Pregnant or breast feeding

- Short bowel syndrome due to multiple small bowel resections

- Presence of a stoma
We found this trial at
71
sites
Long Island Clinical Research Associates, LLP
Great Neck, New York 11021
2412
mi
from 98109
Great Neck, NY
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Shands Hospital at the University of Florida
Gainesville, Florida 32610
2450
mi
from 98109
Gainesville, FL
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University of Miami
Miami, Florida 33124
(305) 284-2211
University of Miami A private research university with more than 15,000 students from around the...
2730
mi
from 98109
Miami, FL
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Internal Medicine Specialists
Orlando, Florida 32806
2549
mi
from 98109
Orlando, FL
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Albany Medical College
47 New Scotland Ave
Albany, New York 12208
(518) 262-3125
Albany Medical College Albany Medical Center is northeastern New York's only academic health sciences center...
2353
mi
from 98109
Albany, NY
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Connecticut Clinical Research Foundation
Bristol, Connecticut 06010
2420
mi
from 98109
Bristol, CT
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Life Medi-Research and Management
Brooklyn, New York 11206
2403
mi
from 98109
Brooklyn, NY
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North Carolina Memorial Hospital Endoscopy Center
Chapel Hill, North Carolina 27514
2335
mi
from 98109
Chapel Hill, NC
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CTRC Hospital - UNC Memorial Hospital
Chapel Hill, North Carolina 27514
2167
mi
from 98109
Chapel Hill, NC
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UNC Hospitals Department of Pharmacy
Chapel Hill, North Carolina 27514
2335
mi
from 98109
Chapel Hill, NC
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UNC Hospitals Endoscopy
Chapel Hill, North Carolina 27517
2337
mi
from 98109
Chapel Hill, NC
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Charlottesville Medical Research Inc.
Charlottesville, Virginia 22911
2286
mi
from 98109
Charlottesville, VA
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Charlottesville Gastroenterology Associates
Charlottesville, Virginia 22902
2285
mi
from 98109
Charlottesville, VA
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Metropolitan Gastroenterology Group, PC Chevy Chase Clinical Research
Chevy Chase, Maryland 20815
2317
mi
from 98109
Chevy Chase, MD
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Iowa Digestive Disease Center
Clive, Iowa 50325
1455
mi
from 98109
Clive, IA
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Heartland Medical Research, Inc (Administrative Only)
Clive, Iowa 50325
1455
mi
from 98109
Clive, IA
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Iowa Endoscopy Center (Colonoscopy Only)
Clive, Iowa 50325
1455
mi
from 98109
Clive, IA
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Surgery Center of Columbia
Columbia, Missouri 65201
1611
mi
from 98109
Columbia, MO
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Pharma Resource
East Providence, Rhode Island 02915
2487
mi
from 98109
East Providence, RI
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The Offices of Dr. Vincent Armenio, M.D.
East Providence, Rhode Island 02914
2488
mi
from 98109
East Providence, RI
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New York Hospital- Queens
Flushing, New York 11355
2409
mi
from 98109
Flushing, NY
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Shands Endoscopy Center
Gainesville, Florida 32608
2453
mi
from 98109
Gainesville, FL
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Shands Medical Plaza
Gainesville, Florida 32608
2452
mi
from 98109
Gainesville, FL
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Nassau Gastroenterology Associates, PC
Great Neck, New York 11021
2412
mi
from 98109
Great Neck, NY
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Nassau Gastroenterology Associates, PC
Great Neck, New York 11021
2412
mi
from 98109
Great Neck, NY
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North Shore Primary Care, P.C.
Great Neck, New York 11021
2412
mi
from 98109
Great Neck, NY
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Nassau Gastroenterology Associates Office Based Surgery
Great Neck, New York 11021
2411
mi
from 98109
Great Neck, NY
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Hillsborough Campus
Hillsborough, North Carolina 27278
2329
mi
from 98109
Hillsborough, NC
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Mayo Clinic, Jacksonville
Jacksonville, Florida 32216
2457
mi
from 98109
Jacksonville, FL
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Gastroenterology Specialists of Arkansas
Jonesboro, Arkansas 72401
1806
mi
from 98109
Jonesboro, AR
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Clopton Clinic
Jonesboro, Arkansas 72401
1806
mi
from 98109
Jonesboro, AR
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UCSD Medical Center, Thornton Hospital
La Jolla, California 92037
1056
mi
from 98109
La Jolla, CA
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Clinical Research of the Rockies
LaFayette, Colorado 80026
1005
mi
from 98109
LaFayette, CO
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Florida Center for Gastroenterology
Largo, Florida 33777
2513
mi
from 98109
Largo, FL
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Little Rock Diagnostic Clinic
Little Rock, Arkansas 72205
1779
mi
from 98109
Little Rock, AR
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Center for Digestive & Liver Diseases Inc.
Mexico, Missouri 65265
1623
mi
from 98109
Mexico, MO
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Audrain Medical Center
Mexico, Missouri 65265
1624
mi
from 98109
Mexico, MO
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University of Miami Hospital
1400 NW 12th Ave
Miami, Florida 33136
(305) 689-5511
University of Miami Hospital The University of Miami changed the face of modern health care...
2730
mi
from 98109
Miami, FL
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University of Miami Hospital and Clinic
Miami, Florida 33136
2730
mi
from 98109
Miami, FL
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Sylvester Comprehensive Cancer Center
Miami, Florida 33136
2730
mi
from 98109
Miami, FL
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Minneapolis Heart Institute, West Health Campus
Minneapolis, Minnesota 55404
1392
mi
from 98109
Minneapolis, MN
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Noran Neurology Clinic
Minneapolis, Minnesota 55407
1392
mi
from 98109
Minneapolis, MN
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Nashville Medical Research Institute
Nashville, Tennessee 37205
1969
mi
from 98109
Nashville, TN
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Beth Israel Medical Center - Phillip Ambulatory Care Center
New York, New York 10003
2262
mi
from 98109
New York, NY
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Lenox Hill Endoscopy Center
New York, New York 10075
2402
mi
from 98109
New York, NY
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East side Endoscopy, LLC (for colonscopy testing only)
New York, New York 10010
2262
mi
from 98109
New York, NY
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Community Clinical Trials
Orange, California 92868
984
mi
from 98109
Orange, CA
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Gastro Diagnostics
Orange, California 92868
984
mi
from 98109
Orange, CA
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Cirtus Ambulartory Surgery Center
Orlando, Florida 32806
2547
mi
from 98109
Orlando, FL
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Pasadena Gastroenterology Associates, P.A. dba Digestive Health Center
Pasadena, Texas 77505
1901
mi
from 98109
Pasadena, TX
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Thomas Jefferson University Hospital
111 S 11th St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
2373
mi
from 98109
Philadelphia, PA
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Minnesota Gastroenterology, P.A.
Plymouth, Minnesota 55446
1380
mi
from 98109
Plymouth, MN
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Consulting Radiology (Xray testing only)
Plymouth, Minnesota 55446
1379
mi
from 98109
Plymouth, MN
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Premier Medical Group of the Hudson Valley
243 N Rd
Poughkeepsie, New York 12601
(845) 471-9410
Premier Medical Group of the Hudson Valley Premier Medical Group offers comprehensive, integrated care providing...
2374
mi
from 98109
Poughkeepsie, NY
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Bayside Endoscopy Center
Providence, Rhode Island 02905
2486
mi
from 98109
Providence, RI
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Inland Gastroenterology Medical Associates
Redlands, California 92374
975
mi
from 98109
Redlands, CA
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The Mayo Clinic
Rochester, Minnesota 55905
1450
mi
from 98109
Rochester, MN
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
1718
mi
from 98109
Saint Louis, MO
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University of Utah HSC
Salt Lake City, Utah 84132
702
mi
from 98109
Salt Lake City, UT
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University of Washington Medical Center
1959 NE Pacific St
Seattle, Washington 98195
(206) 598-3300
University of Washington Medical Center University of Washington Medical Center is one of the nation's...
2
mi
from 98109
Seattle, WA
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Barnes-Jewish Hospital (Investigational Drug Services)
St. Louis, Missouri 63108
1717
mi
from 98109
St. Louis, MO
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Center for Advanced Medicine
St. Louis, Missouri 63110
1718
mi
from 98109
St. Louis, MO
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Rocky Mountain Gastroenterology Associates
Thornton, Colorado 80229
1016
mi
from 98109
Thornton, CO
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Center for Digestive Health
Troy, Michigan 48098
1920
mi
from 98109
Troy, MI
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Surgical Centers of Michigan
Troy, Michigan 48098
1920
mi
from 98109
Troy, MI
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Allegiance Research Specialists
Wauwatosa, Wisconsin 53226
1682
mi
from 98109
Wauwatosa, WI
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GI Associates
Wauwatosa, Wisconsin 53226
1681
mi
from 98109
Wauwatosa, WI
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BioMark Research Inc.
Whittier, California 90603
972
mi
from 98109
Whittier, CA
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AKH Wien Universitaetsklinik fuer Innere Medizin III
Wien, 1090
5365
mi
from 98109
Wien,
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University of Massachusetts Worcester
Worcester, Massachusetts 01655
2454
mi
from 98109
Worcester, MA
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UMASS Memorial Medical Center
Worcester, Massachusetts 01605
2454
mi
from 98109
Worcester, MA
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