Study To Test Whether PF-00547659 Is Safe And Improves Disease Symptoms In Patients With Crohn's Disease



Status:Completed
Conditions:Gastrointestinal, Crohns Disease
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - 75
Updated:10/14/2017
Start Date:April 6, 2011
End Date:October 9, 2015

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Trial Summary
Trial Overview
Inclusion Criteria

A Double-blind, Randomized, Placebo-controlled, Dose-ranging Study To Evaluate The Efficacy And Safety Of Pf-00547659 In Subjects With Crohn's Disease (Opera)

Adults with Crohn's disease that is clinically active despite conventional treatment will be
eligible for this study. Patients may receive one of three doses of PF-00547659 (experimental
drug) or placebo (inactive drug). Disease activity will be measured every two weeks.


Inclusion Criteria:

- Subjects must have failed or are intolerant to anti-TNFs and/or immunosuppressants
(AZA, 6-MP, and/or MTX).

- hsCRP greater than 3mg/L

- Ulcerations demonstrated by colonoscopy performed during screening or 8 weeks prior to
screening

Exclusion Criteria:

- Pregnant or breast feeding

- Short bowel syndrome due to multiple small bowel resections

- Presence of a stoma
We found this trial at
71
sites
Thomas Jefferson University Hospital
111 S 11th St
Philadelphia, Pennsylvania 19107
(215) 955-6000
Thomas Jefferson University Hospital Our hospitals in Center City Philadelphia share a 13-acre campus with...
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Shands Hospital at the University of Florida
Gainesville, Florida 32610
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Gainesville, FL
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University of Miami
Miami, Florida 33124
(305) 284-2211
University of Miami A private research university with more than 15,000 students from around the...
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Internal Medicine Specialists
Orlando, Florida 32806
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Orlando, FL
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Albany Medical College
47 New Scotland Ave
Albany, New York 12208
(518) 262-3125
Albany Medical College Albany Medical Center is northeastern New York's only academic health sciences center...
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Connecticut Clinical Research Foundation
Bristol, Connecticut 06010
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Bristol, CT
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Life Medi-Research and Management
Brooklyn, New York 11206
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Brooklyn, NY
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North Carolina Memorial Hospital Endoscopy Center
Chapel Hill, North Carolina 27514
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Chapel Hill, NC
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CTRC Hospital - UNC Memorial Hospital
Chapel Hill, North Carolina 27514
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Chapel Hill, NC
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UNC Hospitals Department of Pharmacy
Chapel Hill, North Carolina 27514
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Chapel Hill, NC
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UNC Hospitals Endoscopy
Chapel Hill, North Carolina 27517
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Chapel Hill, NC
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Charlottesville Medical Research Inc.
Charlottesville, Virginia 22911
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Charlottesville, VA
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Charlottesville Gastroenterology Associates
Charlottesville, Virginia 22902
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Metropolitan Gastroenterology Group, PC Chevy Chase Clinical Research
Chevy Chase, Maryland 20815
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Chevy Chase, MD
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Iowa Digestive Disease Center
Clive, Iowa 50325
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Clive, IA
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Heartland Medical Research, Inc (Administrative Only)
Clive, Iowa 50325
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Clive, IA
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Iowa Endoscopy Center (Colonoscopy Only)
Clive, Iowa 50325
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Clive, IA
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Surgery Center of Columbia
Columbia, Missouri 65201
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Pharma Resource
East Providence, Rhode Island 02915
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East Providence, RI
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The Offices of Dr. Vincent Armenio, M.D.
East Providence, Rhode Island 02914
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East Providence, RI
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New York Hospital- Queens
Flushing, New York 11355
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Flushing, NY
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Shands Endoscopy Center
Gainesville, Florida 32608
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Shands Medical Plaza
Gainesville, Florida 32608
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Long Island Clinical Research Associates, LLP
Great Neck, New York 11021
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Great Neck, NY
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Nassau Gastroenterology Associates, PC
Great Neck, New York 11021
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Great Neck, NY
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Nassau Gastroenterology Associates, PC
Great Neck, New York 11021
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Great Neck, NY
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North Shore Primary Care, P.C.
Great Neck, New York 11021
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Great Neck, NY
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Nassau Gastroenterology Associates Office Based Surgery
Great Neck, New York 11021
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Great Neck, NY
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Hillsborough Campus
Hillsborough, North Carolina 27278
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Hillsborough, NC
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Mayo Clinic, Jacksonville
Jacksonville, Florida 32216
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Jacksonville, FL
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Gastroenterology Specialists of Arkansas
Jonesboro, Arkansas 72401
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Jonesboro, AR
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Clopton Clinic
Jonesboro, Arkansas 72401
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UCSD Medical Center, Thornton Hospital
La Jolla, California 92037
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La Jolla, CA
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Clinical Research of the Rockies
LaFayette, Colorado 80026
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LaFayette, CO
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Florida Center for Gastroenterology
Largo, Florida 33777
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Largo, FL
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Little Rock Diagnostic Clinic
Little Rock, Arkansas 72205
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Little Rock, AR
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Center for Digestive & Liver Diseases Inc.
Mexico, Missouri 65265
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Mexico, MO
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Audrain Medical Center
Mexico, Missouri 65265
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Mexico, MO
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University of Miami Hospital
1400 NW 12th Ave
Miami, Florida 33136
(305) 689-5511
University of Miami Hospital The University of Miami changed the face of modern health care...
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University of Miami Hospital and Clinic
Miami, Florida 33136
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Sylvester Comprehensive Cancer Center
Miami, Florida 33136
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Minneapolis Heart Institute, West Health Campus
Minneapolis, Minnesota 55404
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Minneapolis, MN
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Noran Neurology Clinic
Minneapolis, Minnesota 55407
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Minneapolis, MN
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Nashville Medical Research Institute
Nashville, Tennessee 37205
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Nashville, TN
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Beth Israel Medical Center - Phillip Ambulatory Care Center
New York, New York 10003
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New York, NY
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Lenox Hill Endoscopy Center
New York, New York 10075
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East side Endoscopy, LLC (for colonscopy testing only)
New York, New York 10010
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New York, NY
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Community Clinical Trials
Orange, California 92868
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Orange, CA
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Gastro Diagnostics
Orange, California 92868
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Cirtus Ambulartory Surgery Center
Orlando, Florida 32806
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Orlando, FL
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Pasadena Gastroenterology Associates, P.A. dba Digestive Health Center
Pasadena, Texas 77505
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Pasadena, TX
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Minnesota Gastroenterology, P.A.
Plymouth, Minnesota 55446
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Plymouth, MN
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Consulting Radiology (Xray testing only)
Plymouth, Minnesota 55446
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Plymouth, MN
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Premier Medical Group of the Hudson Valley
243 N Rd
Poughkeepsie, New York 12601
(845) 471-9410
Premier Medical Group of the Hudson Valley Premier Medical Group offers comprehensive, integrated care providing...
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Bayside Endoscopy Center
Providence, Rhode Island 02905
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Providence, RI
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Inland Gastroenterology Medical Associates
Redlands, California 92374
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Redlands, CA
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The Mayo Clinic
Rochester, Minnesota 55905
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Rochester, MN
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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University of Utah HSC
Salt Lake City, Utah 84132
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University of Washington Medical Center
1959 NE Pacific St
Seattle, Washington 98195
(206) 598-3300
University of Washington Medical Center University of Washington Medical Center is one of the nation's...
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Barnes-Jewish Hospital (Investigational Drug Services)
St. Louis, Missouri 63108
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Center for Advanced Medicine
St. Louis, Missouri 63110
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Rocky Mountain Gastroenterology Associates
Thornton, Colorado 80229
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Thornton, CO
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Center for Digestive Health
Troy, Michigan 48098
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Troy, MI
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Surgical Centers of Michigan
Troy, Michigan 48098
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Troy, MI
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Allegiance Research Specialists
Wauwatosa, Wisconsin 53226
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Wauwatosa, WI
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GI Associates
Wauwatosa, Wisconsin 53226
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BioMark Research Inc.
Whittier, California 90603
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Whittier, CA
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AKH Wien Universitaetsklinik fuer Innere Medizin III
Wien, 1090
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Wien,
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University of Massachusetts Worcester
Worcester, Massachusetts 01655
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UMASS Memorial Medical Center
Worcester, Massachusetts 01605
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