A Trial of Magnesium Dependent Tinnitus

Descriptions of tinnitus date back to the time of ancient Egypt, yet science has failed to
unravel the mysterious underlying mechanisms that produce these subjective auditory
perceptions of sound. These perceptions may be manifestations of damage resulting from
noise exposure, ototoxicity, or other abnormal conditions of the auditory system. However,
many individuals have idiopathic tinnitus for which no specific cause can be determined.
Although often presenting in conjunction with hearing loss, the magnitude of hearing loss
does not necessarily correspond with the severity of tinnitus. In addition, some individuals
reporting tinnitus experience concomitant hyperacusis. This relationship suggests these
processes may be linked by underlying imbalances at the level of the hair cell. The possible
influence of magnesium and its antagonist, calcium, has been discussed in the literature as
a contributing factor in the mitigation of noise-induced hearing loss, ototoxicity, and the
hyperexcitability of the auditory system (Cevette et al, 2003). Permanent and temporary
changes in auditory function have been linked to nutritional deficiencies of magnesium.
Magnesium deficiency has resulted in increased susceptibility to noise-induced hearing loss
(Ising et al, 1982; Joachims et al, 1983; Joachims et al, 1987; Scheibe et al, 2000),
ototoxicity (Vormann and Gunther, 1993), and hyperexcitability (Kruse et al, 1932; Cevette
et al, 1989; Bac et al, 1994) of the auditory system.

The recommended daily allowance (RDA) for magnesium in adults is 4.5 mg/kg (Saris et al,
2000); however, all age groups of Americans fall short of the RDA for magnesium by 100 mg
daily (Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, 1997).
This lack of appropriate magnesium intake may have negative consequences. For example, the
putative magnesium mechanism within the auditory system involves a metabolic cellular
cascade of events. Specifically, magnesium deficiency leads to increased permeability of the
calcium channel in the hair cells with a consequent over-influx of calcium, an increased
release of glutamate via exocytosis, and overstimulation of N-methyl-D-aspartate receptors
on the auditory nerve fibers. Recent studies of both noise-induced hearing loss and
idiopathic sensorineural hearing loss have suggested that magnesium supplementation may
lessen the severity of tinnitus in patients. Magnesium improved hearing recovery and
lessened tinnitus in patients with idiopathic sudden hearing loss (Gordin et al, 2002). More
recently, Nageris et al (2004) showed in a well-controlled study that magnesium was a
relatively safe and convenient adjunct to corticosteroid treatment for enhancing the
improvements of hearing in acute-onset sensorineural hearing loss at a dose of 4 g. The
protective effect of magnesium in noise-induced hearing loss has been previously reported
(Ising et al, 1982; Scheibe et al, 2000).

Despite these encouraging findings, no controlled study has examined the effect of magnesium
supplementation for patients with moderate to severe tinnitus.