Macular Ganglion Cell Analysis (GCA) of the Cirrus HD-OCT in Glaucoma

To determine the area under the Receiver Operator Characteristic Curve (AUC) for the
following GCA parameters:

1. Minimum thickness

2. Supero-temporal thickness

3. Superior thickness

4. Supero-nasal thickness

5. Infero-temporal thickness

6. Inferior thickness

7. Infero-nasal thickness

Inclusion Criteria:

- Age of 40 years or older

- Diagnosed to have glaucoma by the Principal Investigator or co-investigator

- Able and willing to make the required study visits

- Able and willing to give consent and follow study instructions

Exclusion Criteria:

Ophthalmic:

- Best corrected visual acuity in either eye worse than 20/40 on a Snellen chart or on
a Snellen equivalent acuity chart.

- Refractive error outside -12.00D to +8.00D spherical range or >-3.00D cylinder.

- Previous vitreoretinal surgery in study eye.

- Vitreoretinal traction or epiretinal membrane in the study eye.

- Any active infection of anterior or posterior segments.

- Evidence of diabetic retinopathy, diabetic macular edema, or other vitreoretinal
disease in the study eye upon dilated examination, or upon evaluation of retinal
photos.

Systemic:

- History of diabetes, leukemia, AIDS, uncontrolled systemic hypertension, dementia or
multiple sclerosis.

- A life threatening or debilitating disease.

- Participation in any study involving a non-FDA approved investigational drug (IND)
within the past month, or ongoing participation in a study with a non-FDA approved or
cleared investigational device (IDE).

- Current or recent (within the past 14 days) use of an agent with photosensitizing
properties by any route (e.g., Visudyne®, ciprofloxacin, Bactrim®, doxycycline,
etc.).

- Concomitant use of hydrochloroquine and/or chloroquine.