Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer
Status: | Active, not recruiting |
---|---|
Conditions: | Breast Cancer, Cancer |
Therapuetic Areas: | Oncology |
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 4/3/2019 |
Start Date: | January 15, 2011 |
A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients With 1-3 Positive Nodes, Hormone Receptor-Positive and HER2-Negative Breast Cancer With Recurrence Score (RS) of 25 or Less. RxPONDER: A Clinical Trial Rx for Positive Node, Endocrine Responsive Breast Cancer
This randomized phase III clinical trial studies how well tamoxifen citrate, anastrozole,
letrozole, or exemestane with or without chemotherapy work in treating patients with breast
cancer that has spread from where it began in the breast to surrounding normal tissue
(invasive). Estrogen can cause the growth of breast cancer cells. Hormone therapy, using
tamoxifen citrate, may fight breast cancer by blocking the use of estrogen by the tumor
cells. Aromatase inhibitors, such as anastrozole, letrozole, and exemestane, may fight breast
cancer by lowering the amount of estrogen the body makes. Drugs used in chemotherapy work in
different ways to stop the growth of tumor cells, either by killing the cells, by stopping
them from dividing, or by stopping them from spreading. It is not yet known whether giving
tamoxifen citrate, anastrozole, letrozole, or exemestane is more effective with combination
chemotherapy in treating patients with breast cancer.
letrozole, or exemestane with or without chemotherapy work in treating patients with breast
cancer that has spread from where it began in the breast to surrounding normal tissue
(invasive). Estrogen can cause the growth of breast cancer cells. Hormone therapy, using
tamoxifen citrate, may fight breast cancer by blocking the use of estrogen by the tumor
cells. Aromatase inhibitors, such as anastrozole, letrozole, and exemestane, may fight breast
cancer by lowering the amount of estrogen the body makes. Drugs used in chemotherapy work in
different ways to stop the growth of tumor cells, either by killing the cells, by stopping
them from dividing, or by stopping them from spreading. It is not yet known whether giving
tamoxifen citrate, anastrozole, letrozole, or exemestane is more effective with combination
chemotherapy in treating patients with breast cancer.
PRIMARY OBJECTIVES:
I. To determine the effect of chemotherapy in patients with node positive breast cancer who
do not have high recurrence scores (RS) by Oncotype DX.
SECONDARY OBJECTIVES:
I. To compare overall survival (OS), distant disease-free survival (DDFS) and local
disease-free interval (LDFI) by receipt of chemotherapy or not and its interaction with RS.
II. To compare the toxicity across the treatment arms. III. To perform other assays or tests
(in particular the prediction analysis of microarray [PAM50] risk of relapse score), as they
are developed and validated that measure potential benefit of chemotherapy and compare them
to Oncotype DX.
IV. To determine the impact of management with Oncotype DX on patient-reported anxiety
(co-primary Health-Related Quality of Life [HRQL] outcome) prior to screening, after
disclosure of test results, and during the randomized trial.
V. To determine the impact of Oncotype DX on the initial management cost of node-positive,
hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative
breast cancer.
VI. To compare patient-reported utilities (e.g., quality of life [QOL]) for those randomized
to chemotherapy versus no chemotherapy.
VII. Using modeling and DFS information from the trial, to estimate the cost-effectiveness of
management with Oncotype DX vs usual care.
VIII. To determine the role of other assays (e.g., PAM50) as predictors of DFS, DDFS, and
LDFI for patients randomized to chemotherapy versus no chemotherapy.
IX. To determine the impact of treatment with chemotherapy versus no chemotherapy on
patient-reported fatigue and cognitive concerns (secondary HRQL outcomes).
X. To determine the impact of management with Oncotype DX on patient-reported decision
conflict, perceptions regarding Oncotype DX testing, and survivor concerns prior to
screening, after disclosure of test results, and during the randomized trial (secondary HRQL
outcomes).
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive a protocol-approved chemotherapy regimen based on the patient and/or
physician preference. Patients then receive a protocol-approved adjuvant endocrine therapy
comprising tamoxifen citrate, an aromatase inhibitor (anastrozole, letrozole, or exemestane),
or both for 5-10 years in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive a protocol-approved endocrine therapy comprising tamoxifen citrate,
an aromatase inhibitor (anastrozole, letrozole, or exemestane), or both for 5-10 years in the
absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 1 year,
every 6 months for 4 years, and then yearly for 15 years.
I. To determine the effect of chemotherapy in patients with node positive breast cancer who
do not have high recurrence scores (RS) by Oncotype DX.
SECONDARY OBJECTIVES:
I. To compare overall survival (OS), distant disease-free survival (DDFS) and local
disease-free interval (LDFI) by receipt of chemotherapy or not and its interaction with RS.
II. To compare the toxicity across the treatment arms. III. To perform other assays or tests
(in particular the prediction analysis of microarray [PAM50] risk of relapse score), as they
are developed and validated that measure potential benefit of chemotherapy and compare them
to Oncotype DX.
IV. To determine the impact of management with Oncotype DX on patient-reported anxiety
(co-primary Health-Related Quality of Life [HRQL] outcome) prior to screening, after
disclosure of test results, and during the randomized trial.
V. To determine the impact of Oncotype DX on the initial management cost of node-positive,
hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative
breast cancer.
VI. To compare patient-reported utilities (e.g., quality of life [QOL]) for those randomized
to chemotherapy versus no chemotherapy.
VII. Using modeling and DFS information from the trial, to estimate the cost-effectiveness of
management with Oncotype DX vs usual care.
VIII. To determine the role of other assays (e.g., PAM50) as predictors of DFS, DDFS, and
LDFI for patients randomized to chemotherapy versus no chemotherapy.
IX. To determine the impact of treatment with chemotherapy versus no chemotherapy on
patient-reported fatigue and cognitive concerns (secondary HRQL outcomes).
X. To determine the impact of management with Oncotype DX on patient-reported decision
conflict, perceptions regarding Oncotype DX testing, and survivor concerns prior to
screening, after disclosure of test results, and during the randomized trial (secondary HRQL
outcomes).
OUTLINE: Patients are randomized to 1 of 2 treatment arms.
ARM I: Patients receive a protocol-approved chemotherapy regimen based on the patient and/or
physician preference. Patients then receive a protocol-approved adjuvant endocrine therapy
comprising tamoxifen citrate, an aromatase inhibitor (anastrozole, letrozole, or exemestane),
or both for 5-10 years in the absence of disease progression or unacceptable toxicity.
ARM II: Patients receive a protocol-approved endocrine therapy comprising tamoxifen citrate,
an aromatase inhibitor (anastrozole, letrozole, or exemestane), or both for 5-10 years in the
absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for 1 year,
every 6 months for 4 years, and then yearly for 15 years.
Inclusion Criteria:
- Patients must have a histologically confirmed diagnosis of node positive (1-3 nodes)
invasive breast carcinoma with positive estrogen and/or progesterone receptor status,
and negative HER-2 status; estrogen and progesterone receptor positivity must be
assessed according to American Society of Clinical Oncology (ASCO)/College of American
Pathologists (CAP) guidelines as either estrogen receptor (ER) or progesterone
receptor (PR) >= 1% positive nuclear staining; HER-2 test result negativity must be
assessed as per ASCO/CAP 2013 guidelines using immunohistochemistry (IHC), in situ
hybridization (ISH) or both; HER-2 is negative if a single test (or all tests)
performed in a tumor specimen show: a) IHC negative (0 or 1+) or b) ISH negative using
single probe or dual probe (average HER-2 copy number < 4.0 signals per cell by single
probe or HER-2/CEP ration < 2.0 with an average copy number < 4.0 signals per cell by
dual probe); if HER-2 IHC is 2+, evaluation for gene amplification (ISH) must be
performed and the ISH must be negative; ISH is not required if IHC is 0 or 1+; HER-2
equivocal is not eligible
- Patients with multifocal, multicentric and synchronous bilateral breast cancers are
allowed
- Multifocal disease is defined as more than one invasive cancer < 2 cm from the
largest lesion within the same breast quadrant; (NOTE: the Oncotype DX testing
must be completed on the largest lesion)
- Multicentric disease is defined as more than one invasive cancer >= 2 cm from the
largest lesion within the same breast quadrant or more than one lesion in
different quadrants (NOTE: Oncotype DX testing should be completed on all tumors
and the determination for eligibility should be made on the highest recurrence
score)
- Synchronous bilateral disease is defined as invasive breast cancer with positive
lymph nodes (axillary or intramammary) in at least one breast, diagnosed within
30 days of each other; (NOTE: the Oncotype DX testing should be completed on both
tumors and the tumor with the highest recurrence score should be used)
- Patients will have undergone axillary staging by sentinel node biopsy or axillary
lymph nodes dissection (ALND); patients must have at least one, but no more than three
known positive lymph nodes (pN1a, pN1b or pN1c); patients with micrometastases as the
only nodal involvement (pN1mi) are not eligible; patients with positive sentinel node
are not required to undergo full axillary lymph node dissection; this is at the
discretion of the treating physician; axillary node evaluation is to be performed per
the standard of care at each institution
- Patients must not have inflammatory breast cancer and must not have metastatic disease
- Patients with a prior diagnosis of contralateral ductal carcinoma in situ (DCIS) are
eligible if they underwent a mastectomy or lumpectomy with whole breast radiation;
prior partial breast irradiation, including brachytherapy, is not allowed; patients
with a prior diagnosis of ipsilateral DCIS or invasive breast cancer who received
radiation to that breast are not eligible
- Patients must have had either breast-conserving surgery with planned radiation therapy
or total mastectomy (with or without planned postmastectomy radiation); patients must
have clear margins from both invasive breast cancer and DCIS (as per local
institutional guidelines); lobular carcinoma in situ (LCIS) at the margins is allowed
- Registration of patients who have not yet undergone Oncotype DX screening must occur
no later than 56 days after definitive surgery; (for all patients, Step 2 Registration
must occur within 84 days after definitive surgery); if the Oncotype DX Breast Cancer
Assay has not been performed, patients must be willing to submit tissue samples for
testing to determine the Recurrence Score value; a representative block or unstained
sections from the representative block are sent directly to Genomic Health for
Oncotype DX Breast Cancer Assay which will be performed according to the standard
commercial process
- If the Oncotype DX Recurrence Score is already known and is 25 or less, the
patient must be registered to Step 2 immediately following Step 1 registration;
if the Oncotype DX Recurrence Score is already known and is greater than 25, the
patient is ineligible
- Patients must have a complete history and physical examination within 28 days prior to
registration
- Patients must have a performance status of 0-2 by Zubrod criteria
- Patients must be able to receive taxane and/or anthracycline based chemotherapy
- Patients must not have begun chemotherapy or endocrine therapy for their breast cancer
prior to registration
- Patients must not require chronic treatment with systemic steroids (inhaled steroids
are allowed) or other immunosuppressive agents
- Patients must not have received an aromatase inhibitor (AI) or a selective estrogen
receptor modulator (SERM) such as tamoxifen or raloxifene within 5 years prior to
registration
- Patients must not be pregnant or nursing; women of reproductive potential must have
agreed to use an effective contraceptive method; a woman is considered to be of
"reproductive potential" if she has had menses at any time in the preceding 12
consecutive months; in addition to routine contraceptive methods, "effective
contraception" also includes heterosexual celibacy and surgery intended to prevent
pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy,
bilateral oophorectomy or bilateral tubal ligation; however, if at any point a
previously celibate patient chooses to become heterosexually active during the time
period for use of contraceptive measures outlined in the protocol, he/she is
responsible for beginning contraceptive measures
- No other prior malignancy is allowed except for adequately treated basal cell (or
squamous cell) skin cancer, in situ cervical cancer, or other cancer for which the
patient has been disease-free for 5 years
- The Quality of Life and Economic Substudy is permanently closed to accrual effective
12/1/12; patients who consented to QOL prior to 12/1/12 should continue to complete
QOL forms per their expectation report; patients who are able to complete a
questionnaire in English must be offered the opportunity to participate in the Quality
of Life and Economic Substudy; (The Quality of Life and Economic Substudy is available
to U.S. INSTITUTIONS ONLY); patients who are not able to complete a questionnaire in
English are registered to S1007 without participating in the Quality of Life and
Economic Substudy
- Patients who consent to participate in the Quality of Life and Economic Substudy
and who do not yet know the results of their Oncotype DX screening must agree to
complete the S1007 Health-Related Quality of Life Questionnaire: Enrollment
between 14 days prior to and 7 days after Step 1 Registration
- Patients who consent to participate in the Quality of Life and Economic Substudy
and who do already know their Oncotype DX Recurrence Score (and it is 25 or less)
will proceed to Step 2 Registration without completing the S1007 Health-Related
Quality of Life Questionnaire Enrollment Form (but will complete the S1007
Health-Related Quality of Life Questionnaire: Randomized Study Form)
- Patients or their legally authorized representative must be informed of the
investigational nature of this study and must sign and give written informed consent
in accordance with institutional and federal guidelines; for Step 1 registration of
patients who have not yet submitted specimens for the Oncotype DX Breast Cancer Assay,
the appropriate consent form is the Step 1 Consent Form; for both Step 1 and Step 2
registration of patients whose Recurrence Score is already known and is 25 or less,
the appropriate consent form is the Step 2 Consent Form
- As a part of the Oncology Patient Enrollment Network (OPEN) registration process the
treating institution's identity is provided in order to ensure that the current
(within 365 days) date of institutional review board approval for this study has been
entered in the system
- STEP 2 REGISTRATION
- Recurrence score (RS) by Oncotype DX must be =< 25
- Step 2 Registration must take place within 84 days after definitive surgery; patients
must not have begun chemotherapy or endocrine therapy for their breast cancer prior to
randomization
- Patients randomized to either arm may also co-enroll in phase III trials that compare
local therapies, or compare systemic therapies (such as chemotherapy, if randomized to
Arm I of S1007)
- The Quality of Life and Economic Substudy is permanently closed to accrual effective
12/1/12; patients at U.S. INSTITUTIONS who consent to participate in the Quality of
Life and Economic Substudy must agree to complete the S1007 Health-Related Quality of
Life Questionnaire: Randomized Study Form after Recurrence Score results and
randomized treatment status are known but before treatment has been initiated
- Patients or their legally authorized representative must be informed of the
investigational nature of this study and must sign and give written informed consent
in accordance with institutional and federal guidelines; for all patients the
appropriate consent form for this registration is the Step 2 Consent
We found this trial at
1455
sites
Bryn Mawr Hospital Bryn Mawr Hospital, a nationally recognized community teaching hospital, is conveniently located...
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1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
Albuquerque, New Mexico 87131
(505) 272-4946
Principal Investigator: Zoneddy R. Dayao
Phone: 505-925-0366
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
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361 Old Belgrade Road
Augusta, Maine 04330
Augusta, Maine 04330
(207) 621-6100
Principal Investigator: Thomas H. Openshaw
Phone: 207-973-4274
Harold Alfond Center for Cancer Care MaineGeneral's Harold Alfond Center for Cancer Care (HACCC) is...
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8600 Old Georgetown Road
Bethesda, Maryland 20814
Bethesda, Maryland 20814
301-896-3100
Principal Investigator: Antonio C. Wolff
Phone: 410-955-8804
Suburban Hospital Suburban Hospital is a community-based, not-for-profit hospital serving Montgomery County and the surrounding...
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2545 Schoenersville Rd
Bethlehem, Pennsylvania 18017
Bethlehem, Pennsylvania 18017
(484) 884-2200
Principal Investigator: Philip J. Stella
Phone: 208-367-7954
Lehigh Valley Hospital - Muhlenberg At Lehigh Valley Health Network, we continually go the extra...
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75 Francis street
Boston, Massachusetts 02115
Boston, Massachusetts 02115
(617) 732-5500
Principal Investigator: Nancy U. Lin
Phone: 877-442-3324
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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330 Brookline Ave
Boston, Massachusetts 02215
Boston, Massachusetts 02215
617-667-7000
Principal Investigator: Nancy U. Lin
Phone: 877-442-3324
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Bremerton, Washington 98310
Principal Investigator: Mehmet S. Copur
Phone: 308-398-6518
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666 Elm Street
Buffalo, New York 14263
Buffalo, New York 14263
(716) 845-2300
Principal Investigator: Ellis G. Levine
Phone: 877-275-7724
Roswell Park Cancer Institute Welcome to Roswell Park Cancer Institute (RPCI), America's first cancer center...
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1 South Prospect Street
Burlington, Vermont 05401
Burlington, Vermont 05401
802-656-8990
Principal Investigator: Farrah B. Khan
Phone: 802-656-4101
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1300 Jefferson Park Avenue
Charlottesville, Virginia 22908
Charlottesville, Virginia 22908
434-243-6784
Principal Investigator: Patrick M. Dillon
Phone: 434-243-6322
University of Virginia Cancer Center We are fortunate in having state of the art clinical...
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1500 E Duarte Rd
Duarte, California 91010
Duarte, California 91010
(626) 256-4673
Principal Investigator: Joanne E. Mortimer
Phone: 800-826-4673
City of Hope Comprehensive Cancer Center City of Hope is a leading research and treatment...
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1 Hurley Plaza
Flint, Michigan 48503
Flint, Michigan 48503
(810) 262-9000
Principal Investigator: Philip J. Stella
Phone: 208-367-7954
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
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4725 North Federal Highway
Fort Lauderdale, Florida 33308
Fort Lauderdale, Florida 33308
(954) 771-8000
Principal Investigator: Michael A. Schwartz
Phone: 305-674-2625
Holy Cross Hospital While spirituality plays an essential role in the way that we minister...
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University of Texas Medical Branch Established in 1891 as the University of Texas Medical Department,...
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University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
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Bronson Methodist Hospital Our healthcare system serves patients and families throughout southwest Michigan and northern...
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200 North Park Street
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
(269) 382-2500
Principal Investigator: Sunil Nagpal
Phone: 616-391-1230
West Michigan Cancer Center In 1994, Borgess Health Alliance and Bronson Healthcare Group opened the...
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1800 West Charleston Boulevard
Las Vegas, Nevada 89102
Las Vegas, Nevada 89102
(702) 383-2000
Principal Investigator: John A. Ellerton
Phone: 702-384-0013
University Medical Center of Southern Nevada University Medical Center is dedicated to providing the highest...
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8700 Beverly Blvd # 8211
Los Angeles, California 90048
Los Angeles, California 90048
(1-800-233-2771)
Principal Investigator: Monica M. Mita
Phone: 310-423-8965
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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777 Hemlock Street
Macon, Georgia 31201
Macon, Georgia 31201
(478) 633-1000
Principal Investigator: Frederick M. Schnell
Phone: 478-633-1226
Medical Center of Central Georgia Navicent Health is a designated Level I Trauma Center and...
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300 Community Drive
Manhasset, New York 11030
Manhasset, New York 11030
(516) 562-0100
Principal Investigator: Jane E. Carleton
Phone: 516-734-8954
North Shore University Hospital North Shore-LIJ Health System includes 16 award-winning hospitals and nearly 400...
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4805 Northeast Glisan Street
Portland, Oregon 97213
Portland, Oregon 97213
(503) 215-1111
Principal Investigator: Gary E. Goodman
Phone: 503-215-2614
Providence Portland Medical Center We strive to give those we serve exceptional, compassionate health care...
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3181 Southwest Sam Jackson Park Road
Portland, Oregon 97239
Portland, Oregon 97239
503 494-8311
Principal Investigator: Kathleen A. Kemmer
Phone: 503-494-1080
Oregon Health and Science University In 1887, the inaugural class of the University of Oregon...
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593 Eddy Street
Providence, Rhode Island 02903
Providence, Rhode Island 02903
401-444-4000
Principal Investigator: Maria Constantinou
Phone: 401-444-1488
Rhode Island Hospital Founded in 1863, Rhode Island Hospital in Providence, RI, is a private,...
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401 College Street
Richmond, Virginia 23298
Richmond, Virginia 23298
(804) 828-0450
Principal Investigator: Harry D. Bear
Phone: 888-823-5923
Virginia Commonwealth University Massey Cancer Center Founded in 1974, VCU Massey Cancer Center is a...
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60 Crittenden Blvd # 70
Rochester, New York 14642
Rochester, New York 14642
(585) 275-2121
Principal Investigator: Paul M. Barr
Phone: 585-275-5830
University of Rochester The University of Rochester is one of the country's top-tier research universities....
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4502 Medical Drive
San Antonio, Texas 78284
San Antonio, Texas 78284
(210) 567-7000
Principal Investigator: Kate I. Lathrop
Phone: 210-450-3800
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
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1100 Fairview Avenue North
Seattle, Washington 98109
Seattle, Washington 98109
(206) 667-5000
Principal Investigator: Julie R. Gralow
Phone: 800-422-6237
Fred Hutchinson Cancer Research Center At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of...
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825 Eastlake Ave E
Seattle, Washington 98109
Seattle, Washington 98109
(206) 288-7222
Principal Investigator: Julie R. Gralow
Phone: 800-422-6237
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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Seattle, Washington 98104
Principal Investigator: Gary E. Goodman
Phone: 206-215-3086
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3900 W Avera Drive
Sioux Falls, South Dakota 57108
Sioux Falls, South Dakota 57108
(605) 322-4700
Principal Investigator: Amy K. Krie
Phone: 888-634-7268
Avera Cancer Institute Avera, the health ministry of the Benedictine and Presentation Sisters, is a...
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601 South Sherman Street
Spokane, Washington 99202
Spokane, Washington 99202
(509) 228-1000
Principal Investigator: Julie R. Gralow
Phone: 800-422-6237
Cancer Care Northwest - Spokane South Cancer Care Northwest is the Inland Northwest’s premier cancer...
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'Aiea, Hawaii 96701
Principal Investigator: Jeffrey L. Berenberg
Phone: 808-586-2979
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98-1079 Moanalua Road
'Aiea, Hawaii 96701
'Aiea, Hawaii 96701
Principal Investigator: Jeffrey L. Berenberg
Phone: 808-586-2979
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Abbotsford, British Columbia
Principal Investigator: Tamana Walia
Phone: 604-851-4710
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Aberdeen, South Dakota 57401
Principal Investigator: Amy K. Krie
Phone: 888-634-7268
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Aberdeen, Washington 98520
Principal Investigator: Gary E. Goodman
Phone: 360-412-8958
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1200 Old York Road
Abington, Pennsylvania 19001
Abington, Pennsylvania 19001
(215) 481–2000
Principal Investigator: Willard G. Andrews
Phone: 215-481-2402
Abington Memorial Hospital Abington Memorial Hospital (AMH) is a 665-bed, regional referral center and teaching...
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Adrian, Michigan 49221
Principal Investigator: Rex B. Mowat
Phone: 517-265-0116
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Bixby Medical Center ProMedica's Mission is to improve your health and well-being. Which is why,...
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Akron, Ohio 44304
Principal Investigator: Jennifer E. Payne
Phone: 330-615-4132
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Alamosa, Colorado 81101
Principal Investigator: Anthony D. Elias
Phone: 720-848-0650
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Albany, Georgia 31701
Principal Investigator: Sharad A. Ghamande
Phone: 706-721-1663
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Albuquerque, New Mexico 87110
Principal Investigator: Zoneddy R. Dayao
Phone: 505-925-0366
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Alexandria, Louisiana 71301
Principal Investigator: John T. Cole
Phone: 504-842-3708
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Allentown, Pennsylvania 18103
Principal Investigator: Philip J. Stella
Phone: 208-367-7954
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Amarillo, Texas 79106
Principal Investigator: Brian T. Pruitt
Phone: 806-212-1985
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170 North 1100 East
American Fork, Utah 84003
American Fork, Utah 84003
Principal Investigator: Derrick S. Haslem
Phone: 801-408-1347
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Ames, Iowa 50010
Principal Investigator: Joseph J. Merchant
Phone: 515-239-2621
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Anaconda, Montana 59711
Principal Investigator: Benjamin T. Marchello
Phone: 406-969-6060
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Anaheim, California 92806
Principal Investigator: Han A. Koh
Phone: 626-564-3455
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 503-215-2614
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 99504
Principal Investigator: Keith S. Lanier
Phone: 503-215-2614
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Anchorage, Alaska 99508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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Anchorage, Alaska 98508
Principal Investigator: Gary E. Goodman
Phone: 907-212-6871
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2000 E Greenville St
Anderson, South Carolina 29621
Anderson, South Carolina 29621
(864) 512-4640
Principal Investigator: John E. Doster
Phone: 864-512-1000
AnMedical Health Cancer Center Cancer is the general term for a group of more than...
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5301 McAuley Drive
Ann Arbor, Michigan 48197
Ann Arbor, Michigan 48197
734-712-3456
Principal Investigator: Philip J. Stella
Phone: 208-367-7954
Saint Joseph Mercy Hospital St. Joseph Mercy Ann Arbor Hospital is a 537-bed teaching hospital...
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1500 East Medical Center Drive
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
800-865-1125
Principal Investigator: Anne F. Schott
University of Michigan Comprehensive Cancer Center The U-M Comprehensive Cancer Center's mission is the conquest...
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Antigo, Wisconsin 54409
Principal Investigator: Harish G. Ahuja
Phone: 877-405-6866
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Antioch, California 94531
Principal Investigator: Jennifer M. Suga
Phone: 510-891-3400
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Appleton, Wisconsin 54913
Principal Investigator: William A. Conkright
Phone: 920-749-1171
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364 White Oak St
Asheboro, North Carolina 27203
Asheboro, North Carolina 27203
(336) 625-5151
Principal Investigator: Vinay K. Gudena
Phone: 336-832-0821
Randolph Hospital Since 1932, Randolph Hospital has been fortunate to employ dedicated and loyal personnel...
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Asheville, North Carolina 28801
Principal Investigator: Cameron B. Harkness
Phone: 828-213-4150
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Asheville, North Carolina 28801
Principal Investigator: Cameron B. Harkness
Phone: 828-213-4150
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Asheville, North Carolina 28801
Principal Investigator: Cameron B. Harkness
Phone: 828-213-4150
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Asheville, North Carolina 28816
Principal Investigator: Cameron B. Harkness
Phone: 828-213-4150
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Ashland, Kentucky 41101
Principal Investigator: David K. Goebel
Phone: 888-823-5923
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Piedmont Hospital For more than a century, Piedmont Healthcare has been a recognized leader in...
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1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
Atlanta, Georgia 30342
(404) 851-8000
Principal Investigator: Kelly A. May
Phone: 404-303-3355
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
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Emory University Hospital Midtown Emory University Hospital Midtown is a 511-bed community-based, acute care teaching...
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Attleboro, Massachusetts 02703
Principal Investigator: Jonathan B. Croopnick
Phone: 508-236-7059
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Auburn, California 95602
Principal Investigator: Ari D. Baron
Phone: 415-209-2686
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Auburn, California 95603
Principal Investigator: Ari D. Baron
Phone: 415-209-2686
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Auburn, Washington 98001
Principal Investigator: John A. Keech
Phone: 907-458-5380
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