A Study of Response-Guided Duration of Combination Therapy With GS-9451, Pegasys® and Copegus® With and Without Tegobuvir (GS-9190) in Previously Untreated Subjects With Genotype 1 Chronic Hepatitis C



Status:Archived
Conditions:Hepatitis
Therapuetic Areas:Immunology / Infectious Diseases
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:December 2010
End Date:December 2015

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Trial Evaluating 16 and 24 Weeks of Four-Drug Regimen and 24 Weeks of a Three-Drug Regimen of GS-9451, Peginterferon Alfa 2a (PEG, Pegasys®) and Ribavirin (RBV, Copegus®) With and Without Tegobuvir (GS-9190) Followed by Response Guided PEG and RBV in Treatment Naïve Subjects With Chronic Genotype 1 Hepatitis C Virus Infection (Protocol No. GS US 196 0140


This phase 2b study will evaluate the efficacy and safety of 16 and 24 weeks of a 4-drug
regimen with GS-9451 and Tegobuvir and 24 weeks of a 3-drug regimen of GS-9451 without
Tegobuvir, all with Peginterferon Alfa-2a (Pegasys®) and Ribavirin (Copegus®).



We found this trial at
83
sites
University of Louisville Hospital
530 S Jackson St
Louisville, Kentucky 40202
502-562-3226
University of Louisville Hospital As the academic hospital at the heart of the Louisville Metro...
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Avail Clinical Research
860 Peachwood Drive
DeLand, Florida 32720
(386) 740-0770
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Johns Hopkins University
3400 N Charles St
Baltimore, Maryland 21205
410-516-8000
Johns Hopkins University The Johns Hopkins University opened in 1876, with the inauguration of its...
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Comprehensive Clinical Research
175 Cross Keys Rd.
Berlin, New Jersey 08009
856-753-7335
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Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Northwestern University
201 East Huron Street
Chicago, Illinois 60611
(847) 491-3741
Northwestern University Northwestern is recognized both nationally and internationally for the quality of its educational...
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University of Chicago
5801 South Ellis Avenue
Chicago, Illinois 60637
 773.702.1234
University of Chicago One of the world's premier academic and research institutions, the University of...
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University of Cincinnati Medical Center
234 Goodman Dr
Cincinnati, Ohio 45229
(513) 584-1000
University of Cincinnati Medical Center Opening in 1823 as the country
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UT Soutwestern Medical Center at Dallas
5303 Harry Hines Boulevard
Dallas, Texas 75390
(214) 648-3111
UT Soutwestern Medical Center at Dallas UT Southwestern Medical Center is distinctive for its overall...
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University of Florida Gainesville
Gainesville, Florida 32611
(352) 392-3261
University of Florida Gainesville UF has a long history of established programs in international education,...
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Kelsey Research Foundation
5615 Kirby Dr.
Houston, Texas 77005
713-442-1223
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Indiana University
425 University Blvd.
Indianapolis, Indiana 46202
(317) 274-4591
Indiana University INDIANA UNIVERSITY is a major multi-campus public research institution, grounded in the liberal...
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Cedars-Sinai Medical Center
8700 Beverly Blvd # 8211
Los Angeles, California 90048
(1-800-233-2771)
Cedars Sinai Med Ctr Cedars-Sinai is known for providing the highest quality patient care. Our...
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North Shore University Hospital
300 Community Drive
Manhasset, New York 11030
(516) 562-0100
North Shore University Hospital North Shore-LIJ Health System includes 16 award-winning hospitals and nearly 400...
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Mount Sinai Hospital
1 Gustave L Levy Pl # 271
New York, New York 10029
 (212) 241-6500
Mount Sinai Med Ctr Founded in 1852, The Mount Sinai Hospital is a 1,171-bed, tertiary-care...
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Washington Hospital Center
110 Irving St NW # 3B28
Washington, Washington DC 20010
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UNM Health Sciences Center
Albuquerque, New Mexico 87106
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The North Texas Research Institute
Arlington, Texas 76012
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Asheville Gastroenterology Associates, P.A.
Asheville, North Carolina 28801
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Atlanta Gastroenterology Associates
Atlanta, Georgia 30342
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Liver Center of Atlanta
Atlanta, Georgia 30309
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Emory University Hospital - Atlanta
Atlanta, Georgia 30322
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Pacific Oaks Medical Group
Beverly Hills, California 90211
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Binghamton Gastroenterology
Binghamton, New York 13903
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University of Colorado, Boulder
Boulder, Colorado 80309
(303) 492-1411
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Graves-Gilbert Clinic
Bowling Green, Kentucky 42101
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Bach and Godofsky Infectious Diseases
Bradenton, Florida 34209
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Gastroenterology Associates
Bristol, Tennessee 37620
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Albert Einstein College of Medicine
1300 Morris Park Ave
Bronx, New York 10461
(718) 430-2000
Albert Einstein College of Medicine The Albert Einstein College of Medicine of Yeshiva University is...
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Medical University of South Carolina
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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eStudySite
Chula Vista, California 91911
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Consultants for Clinical Research Inc.
Cincinnati, Ohio 45219
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Case Western Reserve Univ
10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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Dekalb Gastroenterology
Decatur, Georgia 30033
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Infectious Disease Specialists of America
Decatur, Georgia 30033
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Josephine Ford Cancer Center at Henry Ford Hospital
2799 W Grand Blvd
Detroit, Michigan 48202
(888) 777-4167
Josephine Ford Cancer Center at Henry Ford Hospital A diagnosis of cancer is one of...
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Digestive Health Specialists of the Southeast
Dothan, Alabama 36305
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Duke Univ Med Ctr
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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South Denver Gastroenterology
Englewood, Colorado 80113
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Metropolitan Research
Fairfax, Virginia 22031
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US Army Institute of Surgical Research
Ft Sam Houston, Texas 78234
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Memphis Gastroenterology Group
Germantown, Tennessee 38138
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Palmetto Research
Hialeah, Florida 33016
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ID Care 105
Hillsborough, New Jersey 08844
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Digestive Associates of Houston
Houston, Texas 77030
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Advanced Liver Therapies
Houston, Texas 77030
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Amcare Research Inc.
Houston, Texas 77090
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Research Specialists of Texas
Houston, Texas 77030
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IGRF
Indianapolis, Indiana 46237
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Gastroenterology Associates, PA
Jackson, Mississippi 39202
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Scripps HealthCare
LaJolla, California 92037
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University of Wisconsin-Madison
Madison, Wisconsin 53706
(608) 263-2400
University of Wisconsin-Madison In achievement and prestige, the University of Wisconsin-Madison has long been recognized...
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University of Miami Hospital
1400 NW 12th Ave
Miami, Florida 33136
(305) 689-5511
University of Miami Hospital The University of Miami changed the face of modern health care...
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Alabama Liver & Digestive Specialists (Alds)
Montgomery, Alabama 36116
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Atlantic Research Affiliates, LLC
Morristown, New Jersey 07960
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James H. Quillen VA Medical Center
Mountain Home, Tennessee 37684
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Columbia Medical Group -The First Clinic, Inc.
Nashville, Tennessee 37203
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Synergy Clinical Research Center
National City, California 91950
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UMDNJ-Robert Wood Johnson Medical Center
New Brunswick, New Jersey 08901
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Concorde Medical Group
New York, New York 10016
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Cornell University, Weill Medical College
New York, New York 10021
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New York University Langone Medical Center
550 1st Ave
New York, New York 10016
(212) 263-7300
New York University Langone Medical Center NYU NYU Langone Medical Center, a world-class, patient-centered, integrated,...
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Columbia Presbyterian Med Ctr
722 W 168th St
New York, New York 10032
(212) 305-2500
Columbia Presbyterian Med Ctr On January 1, 1998, The New York Hospital publicly announced its...
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Digestive and Liver Disease Specialists
Norfolk, Virginia 23502
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Norfolk, VA
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Scientific Clinical Research
North Miami, Florida 33161
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Orlando Immunology Center
1701 North Mills Avenue
Orlando, Florida 32803
(407)647-3960
Orlando Immunology Center Orlando Immunology Center , or simply (OIC) is a part of Infectious...
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Florida Hospital
601 E Rollins St
Orlando, Florida 32803
(407) 303-5600
Florida Hospital Florida Hospital is one of the country
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Mayo Clinic Phoenix
Phoenix, Arizona 85054
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Minnesota Gastroenterology, P.A.
Plymouth, Minnesota 55446
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Liver Institute of Virginia, Bon Secours St. Mary's Hospital of Richmond
Richmond, Virginia 23229
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Richmond, VA
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Alamo Medical Research
San Antonio, Texas 78215
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RESEARCH and EDUCATION, INC
San Diego, California 92015
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Medical Associates Research Group
San Diego, California 92123
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VA Medical Center, San Francisco
San Francisco, California 94121
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California Pacific Medical Center
45 Castro Street
San Francisco, California 94114
(415) 600-6000
California Pacific Medical Center California Pacific Medical Center is one of the largest private, not-for-profit,...
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Virginia Mason Medical Center
Seattle, Washington 98101
(888) 862-2737
Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
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St Louis University
St Louis, Missouri 63104
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University of Arizona
Tucson, Arizona 85721
(520) 621-2211
University of Arizona The University of Arizona is a premier, public research university. Established in...
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Options Health Research, LLC
Tulsa, Oklahoma 74104
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Kaiser Permanente
Vallejo, California 94589
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South Florida Center of Gastroenterology, LLC
Wellington, Florida 33414
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Partners in Internal Medicine, P.C.
Worcester, Massachusetts 01608
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