Effect of Vitamin D Replacement on Insulin Sensitivity
| Status: | Completed |
|---|---|
| Conditions: | Endocrine, Gastrointestinal |
| Therapuetic Areas: | Endocrinology, Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 3/30/2013 |
| Start Date: | January 2011 |
| End Date: | January 2012 |
| Contact: | Vinaya Simha, MD |
| Email: | vinaya.simha@ttuhsc.edu |
| Phone: | 432-335-5250 |
Effect of Vitamin D Supplementation on Insulin Sensitivity and Retinol-binding Protein 4 Levels in Subjects With Vitamin D Deficiency
Healthy subjects with low Vitamin D levels will be randomly assigned to either Vitamin D
replacement or placebo for a period of 8 weeks. Insulin sensitivity will be measured before
and after the intervention, and the changes will be compared between the two groups. This
will help us understand if Vitamin D replacement improves insulin sensitivity. Serum Retinol
Binding Protein 4 levels will also be measured to see if changes in insulin sensitivity are
mediated by RBP4.
Inclusion Criteria:
- 1. Age 18-60 years 2. No known medical illnesses requiring pharmacotherapy 3. Not on
any mineral or vitamin supplements in the last 3 months
Exclusion Criteria:
- 1. Subjects requiring prompt initiation of pharmacotherapy, such as those with
incidentally discovered diabetes mellitus or hypertension.
2. Previous administration of glucocorticoids, retinoic acid derivatives, or insulin
sensitizers in the preceding 3 months.
3. Bariatric surgery or liposuction 4. Unintentional weight loss >5% of the body
weight in last 3 months 5. Chronic smokers (> 1 pk/d for 10 years) 6. Alcohol use > 2
drinks/day
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