Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites in Human Brain and Muscle
| Status: | Recruiting |
|---|---|
| Conditions: | Healthy Studies, Neurology |
| Therapuetic Areas: | Neurology, Other |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 3/24/2019 |
| Start Date: | December 23, 2010 |
| Contact: | Shizhe Steve Li, Ph.D. |
| Email: | steveli@mail.nih.gov |
| Phone: | (301) 435-8859 |
Background:
- Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of
the human body and evaluate activity in the brain. A particular MRI method called magnetic
resonance spectroscopy (MRS) can be used to study brain chemistry as well, which may help
researchers who are studying new treatments for psychiatric illnesses. Researchers are
interested in improving current MRI and MRS techniques, as well as developing new MRI and MRS
techniques to view and measure brain chemicals and brain activity.
Objectives:
- To implement, develop, and optimize brain chemistry imaging techniques using magnetic
resonance imaging and magnetic resonance spectroscopy.
Eligibility:
- Healthy individuals between 18 and 65 years of age.
Design:
- This study will involve a screening visit and a scanning visit at the National
Institutes of Health Clinical Center.
- Participants will be screened with a full medical and physical examination, blood and
urine tests, and neurological testing.
- During the second visit, participants will have an MRI scan of the brain. (Participants
who have received an MRI within the past year will not need to have a second one; the
images of the previous scan will be used for this study.) All participants will then
have an MRS scan using the same scanning equipment.
- Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of
the human body and evaluate activity in the brain. A particular MRI method called magnetic
resonance spectroscopy (MRS) can be used to study brain chemistry as well, which may help
researchers who are studying new treatments for psychiatric illnesses. Researchers are
interested in improving current MRI and MRS techniques, as well as developing new MRI and MRS
techniques to view and measure brain chemicals and brain activity.
Objectives:
- To implement, develop, and optimize brain chemistry imaging techniques using magnetic
resonance imaging and magnetic resonance spectroscopy.
Eligibility:
- Healthy individuals between 18 and 65 years of age.
Design:
- This study will involve a screening visit and a scanning visit at the National
Institutes of Health Clinical Center.
- Participants will be screened with a full medical and physical examination, blood and
urine tests, and neurological testing.
- During the second visit, participants will have an MRI scan of the brain. (Participants
who have received an MRI within the past year will not need to have a second one; the
images of the previous scan will be used for this study.) All participants will then
have an MRS scan using the same scanning equipment.
Magnetic resonance spectroscopy (MRS) is identical to MRI except that the metabolite signal,
rather than the dominant water signal, is measured. Proton (1H) MRS and phosphorous (P) MRS
are two powerful spectroscopy methods to measure metabolism in vivo.
By using water suppression techniques, proton MRS can monitor levels of important brain
metabolites and neurotransmitters such as N-acetylaspartate (NAA), creatine, choline,
lactate, myo-inositol, glutamate, glutamine, gamma aminobutyric acid (GABA), and glutathione.
P MRS can be utilized to measure energy phosphate metabolites of inorganic phosphate (Pi),
phosphocreatine (PCr), adenosine diphosphate (ADP), and adenosine triphosphate (ATP) in brain
and muscle. In addition, phosphocholine (PC), phosphoethanolamine (PE), glycerophosphocholine
(GPC) and glyceophosphoethanolamine (GPE) can also be detected in brain tissues.
This protocol proposes three main goals. First, to implement and optimize current proton and
P MRS methods published in the literature for the imaging of metabolites in human brain and
muscle. Second, to further develop new methods for use in similar brain and muscle MRS
applications. Third, to exchange MRS data with other studies in order to provide data
analysis and quality control for the studies under this, other NIH, or outside protocols.
To develop and optimize in vivo MRS methods, 300 healthy volunteers will be recruited over a
period of ten years. The subjects will be aged 18-65 years, and include representative
numbers of males, females, and minorities.
The experiments will be performed on the GE 3T, Siemens 3T and 7T MRI scanners located at the
NIH In Vivo NMR Research Center. In the first portion of the study, a clinical MRI will be
performed to ensure the subject has no abnormal brain conditions. In the second portion of
the study, MRS scans will be performed in various system and pulse parameter combinations. No
medications will be involved. Total scan time during the MRS scan will be one to two hours
long.
We expect to obtain high quality proton and/or phosphorous spectroscopy imaging from healthy
volunteers that will help establish accurate and reliable spectroscopy methods for clinical
investigators to perform non-invasive studies of psychiatric, neurological disorders, and
other diseases in human brain or muscle.
rather than the dominant water signal, is measured. Proton (1H) MRS and phosphorous (P) MRS
are two powerful spectroscopy methods to measure metabolism in vivo.
By using water suppression techniques, proton MRS can monitor levels of important brain
metabolites and neurotransmitters such as N-acetylaspartate (NAA), creatine, choline,
lactate, myo-inositol, glutamate, glutamine, gamma aminobutyric acid (GABA), and glutathione.
P MRS can be utilized to measure energy phosphate metabolites of inorganic phosphate (Pi),
phosphocreatine (PCr), adenosine diphosphate (ADP), and adenosine triphosphate (ATP) in brain
and muscle. In addition, phosphocholine (PC), phosphoethanolamine (PE), glycerophosphocholine
(GPC) and glyceophosphoethanolamine (GPE) can also be detected in brain tissues.
This protocol proposes three main goals. First, to implement and optimize current proton and
P MRS methods published in the literature for the imaging of metabolites in human brain and
muscle. Second, to further develop new methods for use in similar brain and muscle MRS
applications. Third, to exchange MRS data with other studies in order to provide data
analysis and quality control for the studies under this, other NIH, or outside protocols.
To develop and optimize in vivo MRS methods, 300 healthy volunteers will be recruited over a
period of ten years. The subjects will be aged 18-65 years, and include representative
numbers of males, females, and minorities.
The experiments will be performed on the GE 3T, Siemens 3T and 7T MRI scanners located at the
NIH In Vivo NMR Research Center. In the first portion of the study, a clinical MRI will be
performed to ensure the subject has no abnormal brain conditions. In the second portion of
the study, MRS scans will be performed in various system and pulse parameter combinations. No
medications will be involved. Total scan time during the MRS scan will be one to two hours
long.
We expect to obtain high quality proton and/or phosphorous spectroscopy imaging from healthy
volunteers that will help establish accurate and reliable spectroscopy methods for clinical
investigators to perform non-invasive studies of psychiatric, neurological disorders, and
other diseases in human brain or muscle.
- INCLUSION CRITERIA:
- 18-65 years of age
- able to give written informed consent
- healthy based on medical history and physical exam
- enrolled in Protocol 01-M-0254 or Protocol 17-M-0181
EXCLUSION CRITERIA:
- Any current Axis 1 diagnosis
- Clinically significant laboratory abnormalities
- Positive HIV test
- Metallic foreign bodies that would be affected by the magnetic resonance imaging (MRI)
magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI
scan.
- History of neurological illness or injury with the potential to affect study data
interpretation, such as multiple sclerosis, Parkinson s disease, seizure disorder or
traumatic brain injury
- Inability to lie flat on camera bed for about two and a half hours
Pregnant or breastfeeding
- Current substance use disorder based on DSM-5
- NIMH employees and staff and their immediate family members will be excluded
from the study per NIMH policy.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
Phone: 800-411-1222
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