Laboratory Study Using Tumor Tissue Samples From Women With Node-Positive Breast Cancer
| Status: | Archived |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | April 2005 |
Levels of Phosphorylated AKT in Patients With Node-Positive Breast Cancer: Correlation With Disease-Free and Overall Survival
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors predict how well patients will respond to treatment.
PURPOSE: This laboratory study is looking at tumor tissue samples from women with
node-positive breast cancer.
OBJECTIVES:
- Determine whether levels of phosphorylated Akt (protein kinase B) are associated with
disease-free and/or overall survival in women with node-positive breast cancer treated
with doxorubicin hydrochloride and cyclophosphamide or doxorubicin hydrochloride,
cyclophosphamide, and paclitaxel on protocol NSABP-B-28.
- Compare whether patients with pAkt-negative vs pAkt-positive tumors have a superior
disease-free survival with the addition of paclitaxel than those treated with
doxorubicin hydrochloride and cyclophosphamide alone.
OUTLINE: Tissue microarray sections are analyzed for levels of pAkt by immunohistochemistry.
PROJECTED ACCRUAL: A total of 3,060 patients will be accrued for this study within 3 years.
We found this trial at
1
site
National Cancer Institute (NCI) The National Cancer Institute (NCI) is part of the National Institutes...
Click here to add this to my saved trials
