Developing Mouse Models of Breast Cancer Using Tissue Samples From Women With Breast Cancer
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 5/6/2018 |
| Start Date: | February 2007 |
| End Date: | May 2018 |
Developing In-Vivo Models of Human Breast Cancer
RATIONALE: Changing the genes in laboratory mice to create a living model of human breast
cancer may help doctors learn more about breast cancer.
PURPOSE: This research study is developing mouse models of breast cancer using tissue samples
that were previously collected from women with breast cancer.
cancer may help doctors learn more about breast cancer.
PURPOSE: This research study is developing mouse models of breast cancer using tissue samples
that were previously collected from women with breast cancer.
OBJECTIVES:
- To develop new in vivo models of human breast cancer.
- To correlate response in this model to actual treatment outcome in patients, if the in
vivo model is proven feasible.
OUTLINE: Previously collected breast tumor fragments are implanted into the renal capsule
site of SCID mouse hosts (mouse with severe combined immune deficiency) to establish
metastatic spread patterns, and both histologic and molecular tumor characteristics.
Patients' medical charts are reviewed to obtain relevant information, including general
demographics, smoking and alcohol use, as well as outcome data such as survival and response
to treatment.
- To develop new in vivo models of human breast cancer.
- To correlate response in this model to actual treatment outcome in patients, if the in
vivo model is proven feasible.
OUTLINE: Previously collected breast tumor fragments are implanted into the renal capsule
site of SCID mouse hosts (mouse with severe combined immune deficiency) to establish
metastatic spread patterns, and both histologic and molecular tumor characteristics.
Patients' medical charts are reviewed to obtain relevant information, including general
demographics, smoking and alcohol use, as well as outcome data such as survival and response
to treatment.
DISEASE CHARACTERISTICS:
- Diagnosis of breast cancer
- Any stage of disease
- Primary or metastatic disease
- Human breast tumor tissues available after the diagnoses have been made
- Enrolled on the ongoing Breast Tissue Repository trial VU-VICC-BRE-03103
- Have consented to the use of their tissues for research purpose
- Hormone receptor status not specified
PATIENT CHARACTERISTICS:
- Menopausal status not specified
PRIOR CONCURRENT THERAPY:
- Not specified
We found this trial at
1
site
2220 Pierce Ave
Nashville, Tennessee 37232
Nashville, Tennessee 37232
615-936-8422
Principal Investigator: Bapsi Chak, MD
Phone: 800-811-8480
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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