Biomarkers in Predicting Response to Treatment in Patients Who Have Undergone Surgery for Pancreatic Cancer
| Status: | Archived |
|---|---|
| Conditions: | Cancer, Cancer, Pancreatic Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | January 2007 |
Developing Predictive Markers of Therapeutic Response in Pancreatic Cancer
RATIONALE: Studying samples of tumor tissue in the laboratory from patients with cancer may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer. It may also help doctors predict how patients will respond to treatment.
PURPOSE: This laboratory study is looking at biomarkers in predicting response to treatment
in patients who have undergone surgery for pancreatic cancer.
OBJECTIVES:
- To correlate pre-treatment biomarkers with recurrence, overall survival, and tumor
response to radiotherapy and chemotherapy in patients with pancreatic cancer.
- To determine if a method of extracting and identifying biomarkers (i.e., secreted
cytokines and growth factors) from tissues of the quantity obtained from typical biopsy
can now be applied in the setting of pancreatic cancer.
OUTLINE: Tumor tissue specimens are obtained from the Vanderbilt Ingram Cancer Center Human
Tissue Acquisition Core and analyzed for biomarkers (e.g., integrity of DNA repair pathways
as analyzed by Rad51 and phosphorylated DNA-PK foci formation). The biomarkers are
correlated with clinical outcomes (recurrence, overall survival, and tumor response to
treatment).
Patients are followed for recurrence, relapse, and death from disease.
We found this trial at
3
sites
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2107 Edward Curd Lane
Nashville, Tennessee 37067
Nashville, Tennessee 37067
615-591-9890
Vanderbilt-Ingram Cancer Center at Franklin The Vanderbilt-Ingram Cancer Center at Franklin is a free-standing radiation...
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