Collecting and Storing Tissue Samples From Patients With Relapsed or Recurrent Non-Hodgkin Lymphoma After Treatment on a Southwest Oncology Group Clinical Trial



Status:Archived
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:March 1993

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Central Lymphoma Repository Tissue Procurement Protocol for Relapse or Recurrent Disease


RATIONALE: Collecting and storing samples of tissue from patients with non-Hodgkin lymphoma
to study in the laboratory may help the study of cancer in the future.

PURPOSE: This laboratory study is collecting and storing tissue samples from patients with
relapsed or recurrent non-Hodgkin lymphoma after treatment on a Southwest Oncology Group
(SWOG) clinical trial.


OBJECTIVES:

- Acquire fresh snap-frozen lymphoma tissue from patients with relapsed or recurrent
non-Hodgkin lymphoma after treatment on a Southwest Oncology Group (SWOG) clinical
trial.

- Establish a standard set of procedures for routine acquisition, banking, and study of
lymphoma tissues within the SWOG.

- Use repository tissue to establish clinical correlations via presently activated
phenotyping studies and future projected molecular studies assessing specimen DNA and
RNA status.

- Examine the biology of therapy failure in relationship to changes in pretreatment and
post-treatment immunophenotypic data.

OUTLINE: This is a multicenter study.

Tissues collected at biopsy are snap-frozen and archived for future molecular and genetic
studies.

PROJECTED ACCRUAL: Not specified


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