Studying a Tumor Marker for Testicular Cancer, Skin Cancer, Small Intestine Cancer, and Pancreatic Cancer
| Status: | Terminated |
|---|---|
| Conditions: | Colorectal Cancer, Skin Cancer, Cancer, Cancer, Pancreatic Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | February 2007 |
| End Date: | September 2012 |
The Role of TAB3 Protein in Tumorigenesis
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This research study is evaluating a tumor marker for testicular cancer, skin
cancer, small intestine cancer, and pancreatic cancer.
help doctors learn more about changes that occur in DNA and identify biomarkers related to
cancer.
PURPOSE: This research study is evaluating a tumor marker for testicular cancer, skin
cancer, small intestine cancer, and pancreatic cancer.
OBJECTIVES:
- To identify TAB3 transcript/protein as a molecular marker of cancer, specifically
testicular, skin, small intestine, and pancreatic cancer.
- To characterize TAB3 and its signaling networks that are involved in tumorigenesis.
OUTLINE: Tumor tissue samples from paraffin-embedded tissue blocks are analyzed for TAB3
transcript and protein expression using in situ hybridization and immunostaining with TAB3
cRNA probe and antibody. Antibodies against the proteins involved in the NFkB signaling
pathway (e.g., p65, TAK1, MyD88, and Akt) are used in the immunostaining assays.
- To identify TAB3 transcript/protein as a molecular marker of cancer, specifically
testicular, skin, small intestine, and pancreatic cancer.
- To characterize TAB3 and its signaling networks that are involved in tumorigenesis.
OUTLINE: Tumor tissue samples from paraffin-embedded tissue blocks are analyzed for TAB3
transcript and protein expression using in situ hybridization and immunostaining with TAB3
cRNA probe and antibody. Antibodies against the proteins involved in the NFkB signaling
pathway (e.g., p65, TAK1, MyD88, and Akt) are used in the immunostaining assays.
DISEASE CHARACTERISTICS:
- Paraffin tissue blocks from surgical pathology cancer cases, specifically testicular,
skin, small intestine, and pancreatic cancer, available
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
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Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center We all know...
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