Studying Biomarkers in Patients With Pancreatic Cancer



Status:Completed
Conditions:Cancer, Cancer, Pancreatic Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:11/30/2013
Start Date:May 2007
End Date:December 2014

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Developing Biomarkers in Pancreatic Cancer


RATIONALE: Studying samples of tissue in the laboratory from patients with cancer may help
doctors identify and learn more about biomarkers related to cancer. It may also help doctors
predict how patients will respond to treatment.

PURPOSE: This research study is studying biomarkers in patients with pancreatic cancer.


OBJECTIVES:

- To determine whether the cellular localization of BRCA1 can predict how patients with
pancreatic cancer will respond to cytotoxic agents (e.g., fluorouracil or gemcitabine
hydrochloride) or radiotherapy.

- To identify pre-treatment markers that can be used to correlate with clinical outcomes
of survival and recurrence.

- To determine if a method of extracting and identifying secreted cytokines and growth
factors from biopsy tissue can now be applied to the pancreatic cancer population.

OUTLINE: Tissue samples from biopsies performed during pancreatectomy are collected from the
Vanderbilt Ingram Cancer Center Human Tissue Acquisition Core for laboratory biomarker
studies. Proteins secreted by cancer cells and/or cancer-associated cells are studied by
extracting and identifying secreted cytokines and growth factors from biopsy tissue. The
integrity of the DNA repair pathway in pancreatic cancer is analyzed by Rad51 and
phosphorylated DNA-PK foci formation. Markers are correlated with clinical outcome.

Patients are followed for recurrence, relapse, and death from disease.

Inclusion criteria

- Any subject with excess tissue collected at time of routine surgery for pancreatic
cancer is eligible.

- All subjects participating in this protocol will be followed for recurrence, relapse
and death from disease
We found this trial at
3
sites
2107 Edward Curd Lane
Nashville, Tennessee 37067
615-591-9890
Vanderbilt-Ingram Cancer Center at Franklin The Vanderbilt-Ingram Cancer Center at Franklin is a free-standing radiation...
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Nashville, TN
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2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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Nashville, TN
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Franklin, TN
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