Studying Fibroblast Activity in Patients With Localized Pancreatic Cancer Undergoing Surgery
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Cancer, Cancer, Pancreatic Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2007 |
Pharmacodynamic Study of Fibroblast Activity Protein in Patients With Localized Pancreas Cancer Undergoing Surgical Resection
RATIONALE: Studying samples of tumor tissue and blood from patients with cancer in the
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer.
PURPOSE: This research study is assessing fibroblast activity in patients with localized
pancreatic cancer undergoing surgery.
laboratory may help doctors learn more about changes that occur in DNA and identify
biomarkers related to cancer.
PURPOSE: This research study is assessing fibroblast activity in patients with localized
pancreatic cancer undergoing surgery.
OBJECTIVES:
Primary
- To assess the degree of fibroblast activation protein (FAP) enzymatic activity at the
tumor site in patients with localized pancreatic cancer.
Secondary
- To explore correlations between tumor stromal FAP enzymatic activity and stromal
α_2-antiplasmin levels.
- To explore correlations between tumor FAP enzymatic activity and plasma dipeptidyl
peptidase and plasma α_2-antiplasmin converting enzyme activity as potential
surrogates.
OUTLINE: Patients undergo fine-needle aspiration of tumor or suspected mass at baseline.
Tumor samples are analyzed by IHC for fibroblast activation protein (FAP) expression,
immunocapture assay for ex vivo FAP enzymatic activity, and western analysis for FAP
concentrations. Blood samples are collected weekly and analyzed for dipeptidyl peptidase
activity by ELISA and α_2-antiplasmin converting enzyme.
Primary
- To assess the degree of fibroblast activation protein (FAP) enzymatic activity at the
tumor site in patients with localized pancreatic cancer.
Secondary
- To explore correlations between tumor stromal FAP enzymatic activity and stromal
α_2-antiplasmin levels.
- To explore correlations between tumor FAP enzymatic activity and plasma dipeptidyl
peptidase and plasma α_2-antiplasmin converting enzyme activity as potential
surrogates.
OUTLINE: Patients undergo fine-needle aspiration of tumor or suspected mass at baseline.
Tumor samples are analyzed by IHC for fibroblast activation protein (FAP) expression,
immunocapture assay for ex vivo FAP enzymatic activity, and western analysis for FAP
concentrations. Blood samples are collected weekly and analyzed for dipeptidyl peptidase
activity by ELISA and α_2-antiplasmin converting enzyme.
DISEASE CHARACTERISTICS:
- Biopsy-proven adenocarcinoma of the pancreas or pancreatic mass suspicious for
pancreatic cancer
- Localized disease
- Scheduled to undergo a resection or exploration of their pancreatic tumor
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
We found this trial at
1
site
Click here to add this to my saved trials
