Immune Response in Peripheral Blood of Patients With Colon Cancer
| Status: | Completed |
|---|---|
| Conditions: | Colorectal Cancer, Cancer, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | July 2004 |
| End Date: | December 2008 |
Immune Studies of Peripheral Blood From Patients With Malignant Disease Gastrointestinal Tract
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help
doctors learn more about changes that may occur in the immune system that may help kill
cancer cells.
PURPOSE: This laboratory study is looking at anticancer immune responses in the peripheral
blood of patients with colon cancer.
doctors learn more about changes that may occur in the immune system that may help kill
cancer cells.
PURPOSE: This laboratory study is looking at anticancer immune responses in the peripheral
blood of patients with colon cancer.
OBJECTIVES:
- Quantify T cells specific for tumor peptides (carcinoembryonic antigen and MUC1) from
the peripheral blood of patients with colon cancer.
OUTLINE: This is an open-label study.
Patients undergo blood collection at time of follow-up, surgery, thoracentesis,
paracentesis, or leukapheresis (≤ 5 times per year). Blood is analyzed for tumor peptides
(carcinoembryonic antigen and MUC1), circulating cytokines, and lymphocyte response by
ELISA, ELISPOT, or intracellular flow.
PROJECTED ACCRUAL: A total of 140 patients will be accrued for this study.
- Quantify T cells specific for tumor peptides (carcinoembryonic antigen and MUC1) from
the peripheral blood of patients with colon cancer.
OUTLINE: This is an open-label study.
Patients undergo blood collection at time of follow-up, surgery, thoracentesis,
paracentesis, or leukapheresis (≤ 5 times per year). Blood is analyzed for tumor peptides
(carcinoembryonic antigen and MUC1), circulating cytokines, and lymphocyte response by
ELISA, ELISPOT, or intracellular flow.
PROJECTED ACCRUAL: A total of 140 patients will be accrued for this study.
DISEASE CHARACTERISTICS:
- Diagnosis of colon cancer
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Not specified
We found this trial at
1
site
1501 North Campbell Avenue
Tucson, Arizona 85719
Tucson, Arizona 85719
(520) 694-CURE (2873)
Arizona Cancer Center at University of Arizona Health Sciences Center Since being established in 1976,...
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