Collecting, Analyzing, and Storing Tissue Samples From Patients With Non-Hodgkin's Lymphoma



Status:Archived
Conditions:Lymphoma
Therapuetic Areas:Oncology
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:February 1989

Use our guide to learn which trials are right for you!

Central Lymphoma Repository Tissue Procurement Protocol


RATIONALE: Collecting and storing samples of tissue from patients with cancer to study in
the laboratory may help doctors learn more about changes that may occur in DNA and identify
biomarkers related to cancer. It may also help doctors learn how patients respond to
treatment.

PURPOSE: This laboratory study is collecting, analyzing, and storing tissue samples from
patients with non-Hodgkin's lymphoma.


OBJECTIVES:

- Establish a central lymphoma tissue repository of fresh snap-frozen tissue from
patients with previously untreated non-Hodgkin's lymphoma (NHL).

- Determine a standard set of procedures for routine acquisition, banking, and study of
these tissue samples.

- Correlate presently activated phenotyping studies and future projected molecular
studies of the DNA and RNA status of these tissue samples with clinical results.

- Correlate pretreatment phenotype or genotype of tissue samples from patients with
intermediate- or high-grade NHL with patient outcome, in terms of complete response
rate, time to progression, and survival.

- Correlate the lymphoma lineage (T-cell vs B-cell), loss of class II human
histocompatibility antigen status (HLA-DR-positive vs HLA-DR-negative), proliferative
index (as measured by Ki-67), and B- or T-cell antigen aberrancy (e.g., lack of Pan B
or T antigen expression) with outcome in patients with intermediate- or high-grade NHL.

OUTLINE: Patients are treated on the SWOG study on which they are enrolled.

Tissue samples obtained before treatment began are banked in a tissue repository.

Samples from patients with intermediate- or high-grade non-Hodgkin's lymphoma are analyzed
by three-stage immunohistochemistry using monoclonal antibodies to B-cell antigens, T-cell
antigens, immunoglobulins, CALLA, HLA-DR, anti-interleukin-2 receptor, and Ki-67 (for the
proliferative index). Phenotype (immune marker status, proliferation status, and activation
status) is correlated with response to treatment, relapse, and overall survival.

PROJECTED ACCRUAL: Approximately 495 patients will be accrued for this study.


We found this trial at
181
sites
9280 SE Sunnybrook Blvd #100
Clackamas, Oregon 97015
(503) 513-3300
Clackamas Radiation Oncology Center State-of-the-art technology and compassionate care come together at Clackamas Radiation Oncology...
1375
mi
from
Clackamas, OR
Click here to add this to my saved trials
1201 Camino de Salud Northeast
Albuquerque, New Mexico 87131
(505) 272-4946
University of New Mexico Cancer Center It’s been 40 years since the New Mexico State...
522
mi
from
Albuquerque, NM
Click here to add this to my saved trials
100 E. Idaho St.
Boise City, Idaho 83712
208-381-2711
1041
mi
from
Boise City, ID
Click here to add this to my saved trials
2720 Clare Avenue
Bremerton, Washington 98310
360-479-6154
Olympic Hematology and Oncology We provide outpatient cancer services in a refined environment designed specifically...
1422
mi
from
Bremerton, WA
Click here to add this to my saved trials
1000 Blythe Blvd
Charlotte, North Carolina 28203
(704) 355-2000
957
mi
from
Charlotte, NC
Click here to add this to my saved trials
200 Hawthorne Lane
Charlotte, North Carolina 28233
704-384-4000
Presbyterian Cancer Center at Presbyterian Hospital At Novant Health Presbyterian Medical Center, we are welcoming...
959
mi
from
Charlotte, NC
Click here to add this to my saved trials
1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
Hurley Medical Center From its founding in 1908, Hurley Medical Center has devoted itself to...
826
mi
from
Flint, MI
Click here to add this to my saved trials
2700 Wayne Memorial Drive
Goldsboro, North Carolina 27534
(919) 736-1110
Wayne Memorial Hospital, Incorporated Wayne Memorial Hospital, an affiliate of Wayne Health Corporation, is home...
1112
mi
from
Goldsboro, NC
Click here to add this to my saved trials
401 W Greenlawn Ave
Lansing, Michigan 48910
777
mi
from
Lansing, MI
Click here to add this to my saved trials
800 Rose St
Lexington, Kentucky 40536
(859) 257-4488
Lucille P. Markey Cancer Center at University of Kentucky The Markey Cancer Center was founded...
725
mi
from
Lexington, KY
Click here to add this to my saved trials
1415 E. Kincaid
Mount Vernon, Washington 98273
360-424-4111
Skagit Valley Hospital Cancer Care Center We know that treatment takes its toll physically, emotionally...
1430
mi
from
Mount Vernon, WA
Click here to add this to my saved trials
3181 SW Sam Jackson Park Rd
Portland, Oregon 97239
(503) 494-5058
Knight Cancer Institute at Oregon Health and Science University Cancer takes many forms. Although cancer...
1384
mi
from
Portland, OR
Click here to add this to my saved trials
19500 10th Ave NE # 100
Poulsbo, Washington 98370
(360) 598-7500
Harrison Poulsbo Hematology and Onocology Harrison Poulsbo's new Hematology & Oncology center provides outpatient cancer...
1426
mi
from
Poulsbo, WA
Click here to add this to my saved trials
4502 Medical Drive
San Antonio, Texas 78284
(210) 567-7000
University of Texas Health Science Center at San Antonio The University of Texas Health Science...
571
mi
from
San Antonio, TX
Click here to add this to my saved trials
1100 Fairview Avenue North
Seattle, Washington 98109
(206) 667-5000
Fred Hutchinson Cancer Research Center At Fred Hutchinson Cancer Research Center, our interdisciplinary teams of...
1410
mi
from
Seattle, WA
Click here to add this to my saved trials
1959 NE Pacific St
Seattle, Washington 98195
(206) 598-4100
University Cancer Center at University of Washington Medical Center The Division of Radiation Oncology's work...
1382
mi
from
Seattle, WA
Click here to add this to my saved trials
201 16th Avenue East
Seattle, Washington 98112
(206) 326-3000
Group Health Central Hospital Group Health Cooperative is a member-governed, nonprofit health care system that...
1409
mi
from
Seattle, WA
Click here to add this to my saved trials
601 South Sherman Street
Spokane, Washington 99202
(509) 228-1000
Cancer Care Northwest - Spokane South Cancer Care Northwest is the Inland Northwest’s premier cancer...
1201
mi
from
Spokane, WA
Click here to add this to my saved trials
1717 S J St
Tacoma, Washington 98405
(253) 426-4101
Franciscan Cancer Center at St. Joseph Medical Center St. Joseph Medical Center is a 361-bed...
1408
mi
from
Tacoma, WA
Click here to add this to my saved trials
12902 USF Magnolia Dr
Tampa, Florida 33612
(888) 663-3488
H. Lee Moffitt Cancer Center & Research Institute Moffitt Cancer Center in Tampa, Florida, has...
1112
mi
from
Tampa, FL
Click here to add this to my saved trials
820 North Chelan Avenue
Wenatchee, Washington 98801
509) 663-8711
Wenatchee Valley Medical Center Established on July 21, 2013, Confluence Health is an affiliation between...
1318
mi
from
Wenatchee, WA
Click here to add this to my saved trials
Anchorage, Alaska 99508
2732
mi
from
Anchorage, AK
Click here to add this to my saved trials
Anderson, South Carolina 29621
875
mi
from
Anderson, SC
Click here to add this to my saved trials
Ann Arbor, Michigan 48706
831
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Ann Arbor, Michigan 48106
801
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
5301 East Huron River Drive
Ann Arbor, Michigan 48106
1.877.590.5995
CCOP - Michigan Cancer Research Consortium The Community Clinical Oncology Program (CCOP) is a comprehensive...
801
mi
from
Ann Arbor, MI
Click here to add this to my saved trials
Atlanta, Georgia 30342
798
mi
from
Atlanta, GA
Click here to add this to my saved trials
5665 Peachtree Dunwoody Rd NE
Atlanta, Georgia 30342
(678) 843-7001
Saint Joseph's Hospital of Atlanta Founded by the Sisters of Mercy in 1880, Saint Joseph
798
mi
from
Atlanta, GA
Click here to add this to my saved trials
1968 Peachtree Rd NW
Atlanta, Georgia 30309
(404) 605-5000
Piedmont Hospital For more than a century, Piedmont Healthcare has been a recognized leader in...
800
mi
from
Atlanta, GA
Click here to add this to my saved trials
1000 Johnson Ferry Rd NE
Atlanta, Georgia 30342
(404) 851-8000
Northside Hospital Northside Hospital-Atlanta (in Sandy Springs) opened in 1970. The original facility had 250...
798
mi
from
Atlanta, GA
Click here to add this to my saved trials
Austell, Georgia 30106
786
mi
from
Austell, GA
Click here to add this to my saved trials
205 Palmer Ave.
Bellefontaine, Ohio 43311
937.592.4015
Mary Rutan Hospital The hospital was endowed by the sale of a farm in Ridgeway...
774
mi
from
Bellefontaine, OH
Click here to add this to my saved trials
Berkeley, California 94704
1330
mi
from
Berkeley, CA
Click here to add this to my saved trials
801 Ostrum St
Bethlehem, Pennsylvania 18015
(484) 526-4000
St Luke'S Hospital And Health Network St. Luke's University Health Network (SLUHN) is a nonprofit,...
1214
mi
from
Bethlehem, PA
Click here to add this to my saved trials
801 N. 29th St
Billings, Montana 59107
406.238.2500
Billings Clinic - Downtown Based in Billings, Montana, Billings Clinic is a community-governed health care...
778
mi
from
Billings, MT
Click here to add this to my saved trials
1101 N 27th St # 201
Billings, Montana 59101
(406) 237-3585
St. Vincent Healthcare Cancer Care Services The Sisters of Charity of Leavenworth, Kansas, founded St....
777
mi
from
Billings, MT
Click here to add this to my saved trials
Billings, Montana 59101
777
mi
from
Billings, MT
Click here to add this to my saved trials
90 Poly Drive, Suite 2
Billings, Montana 59101
(406) 237-5460
Montana Cancer Consortium CCOP The Montana Cancer Consortium is a nonprofit organization whose mission is...
780
mi
from
Billings, MT
Click here to add this to my saved trials
931 Highland Blvd
Bozeman, Montana 59715
(406) 585-5070
Bozeman Deaconess Cancer Center Bozeman Deaconess Cancer Center provides the latest cancer technologies and treatment...
871
mi
from
Bozeman, MT
Click here to add this to my saved trials
Burlingame, California 94010
1338
mi
from
Burlingame, CA
Click here to add this to my saved trials
6501 E 2nd St
Casper, Wyoming 82609
(307) 235-5433
Rocky Mountain Oncology Rocky Mountain Oncology Center is a spacious, comfortable, state-of-the-art 19,000 square foot...
567
mi
from
Casper, WY
Click here to add this to my saved trials
914 S Scheuber Rd
Centralia, Washington 98531
(360) 736-2803
Providence Centralia Hospital We are a 127-bed, not for profit hospital providing emergency, diagnostic, cancer,...
1418
mi
from
Centralia, WA
Click here to add this to my saved trials
505 S Plummer Ave
Chanute, Kansas 66720
(620) 431-7580
Cancer Center of Kansas, PA - Chanute Dr. H.E. Hynes founded Cancer Center of Kansas,...
129
mi
from
Chanute, KS
Click here to add this to my saved trials
272 Hospital Rd
Chillicothe, Ohio 45601
740-779-7500
Adena Regional Medical Center Since 1895, Adena Health System has remained focused on its commitment...
808
mi
from
Chillicothe, OH
Click here to add this to my saved trials
898
mi
from
Cleveland, OH
Click here to add this to my saved trials
1831 Fifth Avenue
Columbus, Georgia 31904
(706) 320-8700
John B. Amos Cancer Center The John B. Amos Cancer Center located in Columbus, Georgia,...
809
mi
from
Columbus, GA
Click here to add this to my saved trials
111 S Grant Avenue
Columbus, Ohio 43215
(614) 566-4321
810
mi
from
Columbus, OH
Click here to add this to my saved trials
810
mi
from
Columbus, OH
Click here to add this to my saved trials
5100 W Broad St
Columbus, Ohio 43228
(614) 544-1000
Doctors Hospital Nationally recognized for care quality and patient safety and satisfaction, Doctors Hospital is...
810
mi
from
Columbus, OH
Click here to add this to my saved trials
793 West State Street
Columbus, Ohio 43222
614-234-5000
Mount Carmel Health - West Hospital Located near downtown Columbus, Mount Carmel West is the...
809
mi
from
Columbus, OH
Click here to add this to my saved trials
142 S Main St
Danville, Virginia 24541
(434) 799-2100
Danville Regional Medical Center For more than 120 years, Danville Regional Medical Center has been...
1013
mi
from
Danville, VA
Click here to add this to my saved trials
Davenport, Iowa 52803
466
mi
from
Davenport, IA
Click here to add this to my saved trials
1 Wyoming St
Dayton, Ohio 45409
(937) 208-2300
746
mi
from
Dayton, OH
Click here to add this to my saved trials
9000 North Main Street
Dayton, Ohio 45415
(937) 734-5800
Samaritan North Cancer Care Center At Good Samaritan Hospital (GSH), our licensed, board-certified staff uses...
743
mi
from
Dayton, OH
Click here to add this to my saved trials
405 W Grand Ave
Dayton, Ohio 45405
(937) 723-3200
Grandview Hospital You'll feel like part of our family when you visit Grandview Medical Center...
745
mi
from
Dayton, OH
Click here to add this to my saved trials
2222 Philadelphia Dr
Dayton, Ohio 45406
(937) 734-2612
Good Samaritan Hospital - Dayton Good Samaritan Hospital (GSH) is passionate about providing the most...
746
mi
from
Dayton, OH
Click here to add this to my saved trials
3123 Research Boulevard Suite 150
Dayton, Ohio 45420
(937) 775-1350
Dayton CCOP We are a regional non-profit cancer research consortium serving the Miami Valley area...
746
mi
from
Dayton, OH
Click here to add this to my saved trials
18101 Oakwood Blvd
Dearborn, Michigan 48124
(313) 593-8620
Oakwood Cancer Center at Oakwood Hospital and Medical Center In today's health care environment, a...
834
mi
from
Dearborn, MI
Click here to add this to my saved trials
805
mi
from
Decatur, GA
Click here to add this to my saved trials
561 W. Central Avenue
Delaware, Ohio 43015
(740) 615-1000
Grady Memorial Hospital As the center of healthcare in Delaware County, Grady Memorial Hospital is...
810
mi
from
Delaware, OH
Click here to add this to my saved trials
Denville, New Jersey 07834
1261
mi
from
Denville, NJ
Click here to add this to my saved trials
4201 St Antoine St
Detroit, Michigan 48201
(313) 577-1429
Wayne State University/Detroit Medical Center Founded in 1868, the Wayne State University School of Medicine...
841
mi
from
Detroit, MI
Click here to add this to my saved trials
2020 Central Ave
Dodge City, Kansas 67801
(620) 227-2488
Cancer Center of Kansas, PA - Dodge City Dr. H.E. Hynes founded Cancer Center of...
120
mi
from
Dodge City, KS
Click here to add this to my saved trials
700 West Central
El Dorado, Kansas 67042
(316) 889-0099
Cancer Center of Kansas, PA - El Dorado Dr. H.E. Hynes founded Cancer Center of...
53
mi
from
El Dorado, KS
Click here to add this to my saved trials
1148
mi
from
Elmira, NY
Click here to add this to my saved trials
Fairfield, California 94533
1314
mi
from
Fairfield, CA
Click here to add this to my saved trials
34515 Ninth Ave. S.
Federal Way, Washington 98003
(253) 944-8100
St. Francis Hospital St. Francis Hospital, conveniently located near the center of Federal Way, serves...
1402
mi
from
Federal Way, WA
Click here to add this to my saved trials
200 West Pearl Street
Findlay, Ohio 45840
419-424-0380
Blanchard Valley Medical Associates Blanchard Valley Medical Associates was founded in 1974 by Dr. William...
789
mi
from
Findlay, OH
Click here to add this to my saved trials
555 East Cheves Street
Florence, South Carolina 29506
843-777-2000
McLeod Regional Medical Center McLeod Health, a regional presence and predominant healthcare organization, is dedicated...
1034
mi
from
Florence, SC
Click here to add this to my saved trials
Fort Scott, Kansas 66701
(620) 223-8589
Cancer Center of Kansas - Fort Scott Dr. H.E. Hynes founded Cancer Center of Kansas,...
168
mi
from
Fort Scott, KS
Click here to add this to my saved trials
105 Mcknight Drive
Franklin, Ohio 45005
513-424-2111
738
mi
from
Franklin, OH
Click here to add this to my saved trials
1117 29th St S Ste 500
Great Falls, Montana 59405
(406) 731-8100
956
mi
from
Great Falls, MT
Click here to add this to my saved trials
Great Falls, Montana 59405
956
mi
from
Great Falls, MT
Click here to add this to my saved trials
1101 26th Street South
Great Falls, Montana 59405
406.455.5000
Sletten Cancer Institute at Benefis Healthcare Benefis Hospitals has 516 beds at its two campuses...
956
mi
from
Great Falls, MT
Click here to add this to my saved trials
835 Sweitzer St
Greenville, Ohio 45331
(937) 548-1141
Wayne Hospital Stretching back to our roots nearly 100 years ago, Wayne HealthCare has always...
726
mi
from
Greenville, OH
Click here to add this to my saved trials
114 Woodland St, Hartford
Hartford, Connecticut 06105
(860) 714-4000
Saint Francis/Mount Sinai Regional Cancer Center at Saint Francis Hospital and Medical Center While better...
1358
mi
from
Hartford, CT
Click here to add this to my saved trials
30 13th St
Havre, Montana 59501
(406) 265-2211
Northern Montana Hospital Northern Montana Hospital (NMH) is the center of a comprehensive system of...
958
mi
from
Havre, MT
Click here to add this to my saved trials
2475 Broadway St
Helena, Montana 59601
(406) 442-2480
St. Peter's Hospital Welcome to St. Peter’s Hospital, providing premier health care to a five–county...
947
mi
from
Helena, MT
Click here to add this to my saved trials
800 N Justice St
Hendersonville, North Carolina 28791
(828) 696-1000
Pardee Memorial Hospital Pardee Hospital is a not-for-profit community hospital founded in 1953 and is...
865
mi
from
Hendersonville, NC
Click here to add this to my saved trials
800 W. Laurel
Independence, Kansas 67301
620-331-4099
Cancer Center of Kansas-Independence Dr. H.E. Hynes founded Cancer Center of Kansas, P. A. in...
120
mi
from
Independence, KS
Click here to add this to my saved trials
205 Northeast Ave
Jackson, Michigan 49201
(517) 788-4800
Foote Memorial Hospital Allegiance Health is a community-owned, locally-governed health system in Jackson, Michigan. We...
774
mi
from
Jackson, MI
Click here to add this to my saved trials
Jackson, Mississippi 39216
571
mi
from
Jackson, MS
Click here to add this to my saved trials
75 Claremont St Ste E
Kalispell, Montana 59901
(406) 752-7600
Glacier Oncology, PLLC Glacier Oncology are physician clinics focusing exclusively on the medical subspecialties of...
1098
mi
from
Kalispell, MT
Click here to add this to my saved trials
310 Sunnyview Ln
Kalispell, Montana 59901
(406) 752-5111
Kalispell Regional Medical Center Nestled in the beautiful Flathead Valley of Northwestern Montana, Kalispell Regional...
1098
mi
from
Kalispell, MT
Click here to add this to my saved trials
Kansas City, Missouri 64131
195
mi
from
Kansas City, MO
Click here to add this to my saved trials
Kansas City, Missouri 64114
193
mi
from
Kansas City, MO
Click here to add this to my saved trials
2800 Clay Edwards Dr
Kansas City, Missouri 64116
(816) 691-2000
North Kansas City Hospital Generations of Northlanders have considered North Kansas City Hospital as their...
200
mi
from
Kansas City, MO
Click here to add this to my saved trials
2316 E Meyer Blvd
Kansas City, Missouri 64132
(816) 276-4000
Research Medical Center Research Medical Center offers hospital and health clinic services across three Kansas...
196
mi
from
Kansas City, MO
Click here to add this to my saved trials
Kansas City, Missouri 64116
200
mi
from
Kansas City, MO
Click here to add this to my saved trials
2301 Holmes
Kansas City, Missouri 64108
816-404-1000
Truman Medical Center Located in the heart of downtown Kansas City, TMC Hospital Hill is...
198
mi
from
Kansas City, MO
Click here to add this to my saved trials
Kearney, Nebraska 68848
213
mi
from
Kearney, NE
Click here to add this to my saved trials
7360 W. Deschutes
Kennewick, Washington 99336
509-783-0144
Columbia Basin Hematology and Oncology Our collaboration with Seattle Cancer Care Alliance gives you convenient...
1236
mi
from
Kennewick, WA
Click here to add this to my saved trials
747
mi
from
Kettering, OH
Click here to add this to my saved trials
750 Avenue D West
Kingman, Kansas 67068
(620) 532-3147
Cancer Center of Kansas, PA - Kingman Dr. H.E. Hynes founded Cancer Center of Kansas,...
18
mi
from
Kingman, KS
Click here to add this to my saved trials
1915 White Ave.
Knoxville, Tennessee 37916
(865) 541-1678
Thompson Cancer Survival Center The Thompson Cancer Survival Center Downtown facility has pioneered many advances...
777
mi
from
Knoxville, TN
Click here to add this to my saved trials
401 N Ewing St
Lancaster, Ohio 43130
(740) 687-8000
Fairfield Medical Center We are people you know offering care you trust. Serving more than...
829
mi
from
Lancaster, OH
Click here to add this to my saved trials
1215 E Michigan Ave
Lansing, Michigan 48912
(517) 364-2890
Sparrow Regional Cancer Center Sparrow has grown to become the region's largest health system, and...
779
mi
from
Lansing, MI
Click here to add this to my saved trials
325 Maine Street
Lawrence, Kansas 66044
(785) 505-5000
Lawrence Memorial Hospital Lawrence Memorial Hospital (LMH), in collaboration with its medical staff, is dedicated...
164
mi
from
Lawrence, KS
Click here to add this to my saved trials
Lawrenceville, Georgia 30045
817
mi
from
Lawrenceville, GA
Click here to add this to my saved trials
Leavenworth, Kansas 66048
189
mi
from
Leavenworth, KS
Click here to add this to my saved trials
100 NE St Lukes Blvd
Lee's Summit, Missouri 64086
(816) 347-5000
Saint Luke's East - Lee's Summit Founded in 2006, Saint Luke
206
mi
from
Lee's Summit, MO
Click here to add this to my saved trials