Impact of Vitamin D Supplementation on Lactation Associated Bone Loss
| Status: | Archived |
|---|---|
| Conditions: | Osteoporosis |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
| Start Date: | December 2009 |
| End Date: | June 2012 |
Studies have shown that lactation is associated with a loss of bone density from four to
seven percent at the spine and hip among women who lactate for six months. Decline in bone
density with lactation occurs rapidly. Although bone density increases after weaning, there
is controversy on whether or not it is completely restored. Epidemiological studies find no
significant negative impact of lactation on bone mass or fractures, and in fact there is
evidence that lactation has a positive effect on bone mass. We think that interventions that
attenuate this physiologic loss of bone that is associated with lactation and accelerate
restoration of bone mass after weaning may result in improved long term bone mass and
diminished fracture risk.
Adequate vitamin D stores are necessary for skeletal health. Vitamin D deficiency is
pronounced in women of child bearing age as well as pregnant women in the United States.
This study will provide important information about whether vitamin D supplementation may
positively impact the normal physiologic loss of bone mass that is observed during
lactation.
Recruitment will begin while subjects are pregnant in order to expedite entry into the study
in the immediate post-partum period. If subjects are deemed eligible during pregnancy,
contact information to include name, address, expected delivery date and two contact phone
numbers will be obtained. Subjects will be contacted two weeks prior to expected delivery
date and then again at expected delivery date. Subjects will be followed for a total of 18
months.
We found this trial at
1
site
Click here to add this to my saved trials
