Arterial Spin Labeling Perfusion Magnetic Resonance (MR) Imaging in Pediatric Brain Tumors

The purpose of this study is to get information regarding the usefulness and accuracy of
this new MRI technique - termed arterial spin labeling (ASL) - in the diagnosis of pediatric
brain tumors. This technique can non-invasively measure the blood flow to the brain during
MRI examination. Because aggressive brain tumors require new blood vessels and a high level
of blood supply to support its growth, we believe the tumor blood flow measured using ASL is
a reliable indicator of tumor grade. This information may be useful for doctors to make
treatment decisions and to monitor patients' response to treatment.

Inclusion Criteria:

- Age 0-18 years

- Primary brain tumor (newly diagnosed or recurrent) with measurable disease (at least
1cm2)

Exclusion Criteria:

- Patients with cardiac pacemaker or ferrous metal foreign bodies

- Patients with medical problems contradictive to receiving MRI scans.

- Patients requiring general anesthesia or sedation for their MRI scan.

- Patients with a history of cerebrovascular disorders (stroke, moya moya) that may
alter cerebral perfusion.