Pre-Operative Staging of Pancreatic Cancer Using Superparamagnetic Iron Oxide Magnetic Resonance Imaging (SPIO MRI)
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Cancer, Pancreatic Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 2/4/2013 |
| Start Date: | July 2008 |
| End Date: | November 2012 |
| Contact: | Ralph Weissleder, MD, PhD |
| Phone: | 6170726-5788 |
Improved Pre-Operative Staging of Pancreatic Cancer Using Superparamagnetic Iron Oxide Magnetic Resonance Imaging (SPIO MRI)
The purpose of this research study is to see if a specific kind of MRI, called Ultrasmall
Superparamagnetic Iron Oxide Magnetic Resonance Imaging (USPIO MRI), which uses an
FDA-approved therapeutic agent(Feraheme) to see if it is able to identify small and
otherwise undetectable lymph node metastases in people who have pancreatic cancer and are
scheduled for surgical resection.
- On the first day, study participants will undergo 2 MRI examinations. A scan will be
done prior to administration of the contrast agent (Feraheme) and then a second scan
immediately after administration. On the second day, study participants will be asked
to return for a third MRI.
- All MRI scans will be done at Massachusetts General Hospital.
Inclusion Criteria:
- Locally resectable pancreatic mass present on one or more pre-operative imaging
modalities
- Must demonstrate no evidence of distant metastases as assessed by
chest/abdomen/pelvis CT scan
- Deemed eligible for resection with curative intent by a treating surgeon who is
listed as an investigator on this study
- 18 years of age or older
- No uncontrolled serious medical or psychiatric illness
- Women of childbearing potential must not be pregnant or lactating
Exclusion Criteria:
- Known allergy to iron or dextran
- Pregnant or lactating
- Counter-indication to MRI, such as the presence of metallic prostheses or implanted
metal device
- Sickle cell disease or hemoglobinopathy
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