Imaging Techniques for Identifying Factors of Sudden Cardiac Death Risk
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/14/2019 |
| Start Date: | October 2003 |
| End Date: | July 2020 |
| Contact: | Robert G. Weiss, MD |
| Email: | rweiss@jhmi.edu |
| Phone: | 410-955-1703 |
Functional Energetics and Imaging for Phenotypic Characterization of Patients at Risk for Sudden Cardiac Death
Sudden cardiac death is a tragic event that strikes all age groups and is unfortunately
increasing in prevalence. Because it is difficult to predict those at highest risk, this
study is designed to test the hypothesis that new imaging techniques (magnetic resonance
imaging [MRI] and computed tomography [CT]) are useful for identifying factors which put
people at high risk for sudden death.
increasing in prevalence. Because it is difficult to predict those at highest risk, this
study is designed to test the hypothesis that new imaging techniques (magnetic resonance
imaging [MRI] and computed tomography [CT]) are useful for identifying factors which put
people at high risk for sudden death.
Some people with heart disease and a weak heart muscle experience abnormal electrical
activity of the heart that may predispose them to sudden death. In light of this risk, it has
been recommended that such patients undergo implantation of an implantable cardioverter
defibrillator (ICD). Your doctors have determined that you are such a patient and are to
undergo implantation of an ICD. It is unclear who among the many patients who undergo ICD
implantation for this reason are at greatest risk of sudden death and therefore require
electrical response from their ICD. This research is being done to determine whether new
imaging tests, such as magnetic resonance imaging (MRI) or multi-detector computed tomography
(MDCT), can be used to predict who is at highest risk of sudden death and require electrical
response from their ICD.
activity of the heart that may predispose them to sudden death. In light of this risk, it has
been recommended that such patients undergo implantation of an implantable cardioverter
defibrillator (ICD). Your doctors have determined that you are such a patient and are to
undergo implantation of an ICD. It is unclear who among the many patients who undergo ICD
implantation for this reason are at greatest risk of sudden death and therefore require
electrical response from their ICD. This research is being done to determine whether new
imaging tests, such as magnetic resonance imaging (MRI) or multi-detector computed tomography
(MDCT), can be used to predict who is at highest risk of sudden death and require electrical
response from their ICD.
Inclusion Criteria:
- Left ventricular ejection fraction <45%
- Planned implantable cardioverter-defibrillator (ICD) implantation for clinical
indications (primary prevention)
Exclusion Criteria:
- History of sudden death (secondary prevention)
- Contraindication to undergoing MRI (metallic implant, pacemaker, etc.)
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