Safety and Effectiveness of the UV-X System for Corneal Collagen Cross-Linking for Compassionate Treatment in Pediatric Patients With Progressive Keratoconus

This is a non-randomized study. All eyes that qualify for the study will receive the
cross-linking (CXL) procedure. Corneal collagen cross-linking is performed as a single
treatment. Depending on the patient's condition, the CXL procedure may be performed under
sedation or anesthesia. Subjects are followed for 12 months after the procedure to evaluate
the long term effects of corneal collagen cross-linking.

Inclusion Criteria:

- Age 6 to 18 years

- Having a diagnosis of progressive keratoconus

- Signed written informed consent

- Having a condition that limits the patient's capacity to comply with the
cross-linking treatment procedures and/or the diagnostic tests and measurements
required by the ongoing clinical studies

- Willingness and ability to comply with schedule for follow-up visits

Exclusion Criteria:

- Corneal pachymetry at the screening exam that is <400 microns at the thinnest point

- Previous ocular condition in the eye(s) to be treated that may predispose the eye for
future complications, for example (herpes simplex, herpes zoster keratitis, recurrent
erosion syndrome, corneal melt, or corneal dystrophy, etc.)

- A history of delayed epithelial healing in the eye(s) to be treated

- Pregnancy or lactation during the course of the study

- A known sensitivity to study medications