Azelaic Acid Versus Hydroquinone in Melasma

Melasma is a chronic condition in which dark areas appear on the forehead, cheeks, and upper
lips. Hydroquinone is a skin lightener (or fade cream) and is one of the most commonly used
medications for the treatment of melasma. Azelaic acid gel is currently used to treat acne
and rosacea.

Inclusion Criteria:

- must have stable moderate-severe epidermal or mixed melasma involving the face

- all races

- males and females

- persons taking birth control medication, hormone replacement therapy or any other
hormone altering medication may participate only if they have not started or stopped
the medication within the last 3 months

Exclusion Criteria:

- if the person has only dermal melasma

- pregnancy, breastfeeding, a positive pregnancy test in the office or plans to become
pregnant

- a known allergy or sensitivity ot azelaic acid or hydroquinone

- the use of photosensitizing medications (ex. tetracycline) within 3 months of the
study.

- starting or stopping hormonal medication within 3 months

- chemical peels, microdermabrasion, or laser treatment within 6 months

- worsening or improving melasma