Efficacy of a Fibrin Sealant in Burn Surgery

Burn patients require extensive split-thickness skin grafting operations. These operations
necessitate excision of burn wounds and the procurement of autografts. Both of these result
in bleeding open wounds. Fibrin sealants may be of benefit in three aspects of burn
surgery:

1. as a hemostatic agent on excised burns,

2. as a hemostatic agent on donor sites, and

3. as a method of fixation of skin grafts to wounds.

Skin grafts are routinely secured with surgical staples. Patients with large burns will
commonly have hundreds, even thousands of staples used during the course of their care.
Problems associated with the use of surgical staples include:

1. discomfort upon removal and

2. staples become deeply embedded in the tissue.

If effective in securing skin grafts, fibrin glue would directly benefit burn patients by
decreasing the number of staples required, and thereby decreasing the number of retained
staples. Fibrin sealant is produced from human fibrinogen and human thrombin from pooled
plasma that is virally inactivated by a two-stage heating process.

Subjects will serve as their own control. They will have an area of their wound treated
with the fibrin sealant and another area treated with the standard of care. Both areas will
be compared for hemostasis, skin graft fixation, wound healing, and cosmetic outcome.