Safety Study of Cervical Sympathetic Block for Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage
| Status: | Terminated |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 9/29/2017 |
| Start Date: | April 2009 |
| End Date: | December 2014 |
Safety and Efficacy of Cervical Sympathetic Block in Patients With Cerebral Vasospasm Following Aneurysmal Subarachnoid Hemorrhage - Pilot Study
To evaluate the feasibility of performing a cervical sympathetic block in patients with
severe cerebral vasospasm involving the anterior cerebral circulation following aneurysmal
SAH.
severe cerebral vasospasm involving the anterior cerebral circulation following aneurysmal
SAH.
Inclusion Criteria:
1. High grade spontaneous SAH (Fisher Grade III and IV)
2. Secured aneurysm (clipped/coiled)
3. Evidence of severe vasospasm - MCA mean flow velocity >200 cm/sec and Lindegaard ratio
>6 OR Symptomatic vasospasm with either angiographic evidence (no angioplasty), or at
least moderate severity according to TCD criteria (MCA mean flow velocity >150 cm/sec
and Lindegaard ratio >3, or ACA vasospasm)
4. Age ≥18
Exclusion Criteria:
1. Allergy to local anesthetic or contrast
2. Coagulation disorders with PT <70%, or INR >1.4, or PTT >1.5 times control and/or
platelets <70,000x106/L
3. Use of enoxaparin within 12 hours
4. Use of clopidogrel within 7 days
5. Use of coumadin within 5 days
6. Use of ticlopidine within 14 days
7. Use of intravenous thrombolytics within 10 days
8. Any use of hirudin derivatives during ICU stay
We found this trial at
1
site
Harborview Medical Center Harborview Medical Center is the only designated Level 1 adult and pediatric...
Click here to add this to my saved trials
