A Study to Evaluate Safety and Tolerability of Multiple Doses of MEDI-546 in Adult Subjects With Scleroderma



Status:Archived
Conditions:Skin and Soft Tissue Infections, Dermatology
Therapuetic Areas:Dermatology / Plastic Surgery
Healthy:No
Age Range:Any
Updated:7/1/2011
Start Date:September 2009
End Date:September 2011

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase 1 Multicenter, Open-label Study to Evaluate the Safety and Tolerability of Single and Multiple Intravenous Doses of MEDI-546, a Fully Human Monoclonal Antibody Directed Against Subunit 1 of the Type I Interferon Receptor, in Adult Subjects With Scleroderma


To evaluate the safety and tolerability of a multiple-dosed drug (MEDI-546) in adults with
scleroderma.


The primary objective of this study is to evaluate the safety and tolerability of single and
multiple IV doses of MEDI-546 in adult subjects with scleroderma who have skin thickening in
an area suitable for repeat biopsy.


We found this trial at
11
sites
University of Michigan Health Systems
1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
University of Michigan Health Systems The University of Michigan is home to one of the...
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Boston Med Center
1 Boston Medical Center Pl
Boston, Massachusetts 02118
617.638.8000
Boston Med Center Boston Medical Center (BMC) is a 496-bed academic medical center located in...
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Boston, MA
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Metroplex Clinical Research Center
8144 Walnut Hill Lane
Northeast, Texas 75231
214-879-6737
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Northeast, TX
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Georgetown Univ Med Ctr
4000 Reservoir Road NW, Suite 120
Washington, Washington DC 20007
(202) 687-0100
Georgetown Univ Med Ctr Georgetown University Medical Center is committed to excellence in research, education...
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Washington, DC
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Houston Medical School
Houston, Texas 77030
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Houston, TX
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North Shore - Long Island Jewish Health System
Lake Success, New York 11042
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Lake Success, NY
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David Geffen School of Medicine, UCLA
10833 Le Conte Ave
Los Angeles, California 90095
(310) 825-4321
David Geffen School of Medicine, UCLA In 2002 Mr. David Geffen announced a $200 million...
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Los Angeles, CA
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University of Medicine and Dentistry - Robert Wood Johnson University Hospital
New Brunswick, New Jersey 08903
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New Brunswick, NJ
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University Of Utah Hospital
Salt Lake City, Utah 84132
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Salt Lake City, UT
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Virginia Mason Medical Center
Seattle, Washington 98101
(888) 862-2737
Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
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Seattle, WA
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University of Toledo Medical Center
Toledo, Ohio 43614
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Toledo, OH
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